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Piperidine hydrochloride

Piperidine hydrochloride Basic information
Product Name:Piperidine hydrochloride
Synonyms:hexahydropyridinehydrochloride;PIPERIDINE HYDROCHLORIDE;PIPERIDINIUM CHLORIDE;PIPERIDINIUM HYDROCHLORIDE;PIPERIDINE HYDROCHLORIDE, CRYSTALLIZED;Piperidinehydrochloride,99%;Piperidiniumchlorid;PIPERIDINE HCL PIPERIDINE HYDROCHLORIDE
CAS:6091-44-7
MF:C5H11N.ClH
MW:121.61
EINECS:228-033-8
Product Categories:Piperidine;Building Blocks;Heterocyclic Building Blocks;Piperidines
Mol File:6091-44-7.mol
Piperidine hydrochloride Structure
Piperidine hydrochloride Chemical Properties
Melting point 245-248 °C(lit.)
Boiling point 347.05℃
density 1,12 g/cm3
vapor density 2.94 (vs air)
vapor pressure 63.6 mm Hg ( 37.8 °C)
Fp >230 °F
storage temp. Store below +30°C.
solubility >1500g/l
form Solid:crystalline
PH6-8 (111g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
BRN 3611699
InChIKeyVEIWYFRREFUNRC-UHFFFAOYSA-N
LogP-1.92
CAS DataBase Reference6091-44-7(CAS DataBase Reference)
EPA Substance Registry SystemPiperidine hydrochloride (6091-44-7)
Safety Information
Hazard Codes T
Risk Statements 25-37-36/37/38-23/24/25
Safety Statements 36/37/39-45-28A-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 1
RTECS TN0400000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29333200
MSDS Information
ProviderLanguage
Piperidine hydrochloride English
SigmaAldrich English
ACROS English
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Piperidine hydrochloride Usage And Synthesis
Chemical PropertiesWHITE FINE CRYSTALLINE POWDER
UsesReagent for synthesis of:
  • Quinoline selenium compounds
  • Peripheral seratonin 5-HT3 receptor ligands

Reactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors

Reactant for:
  • Mannich reactions
  • Asymmetric hydrogenation of quinolines
  • Chemoselective reductive amination of carbonyl compounds
UsesPiperidine hydrochloride is used an intermediate in the manufacture of active pharmaceutical ingredients like anti Parkinsonan agent Biperiden; anti depressant agent Clocapramine hydrochloride and muscle relaxant tolperisone.
Purification MethodsCrystallise the salt from EtOH/diethyl ether in the presence of a small amount of HCl. [Beilstein 20 H 6, 20 II 10, 20 III/IV 295, 20/2 V 13.]
Piperidine hydrochloride Preparation Products And Raw materials
Preparation ProductsPiperidine-->Befunolol-->Bipariden-->3-(1-Piperidinyl)propiophenone HCl-->Diisopropylamine hydrochloride-->2-OXOBUTANALDEHYDE
Tag:Piperidine hydrochloride(6091-44-7) Related Product Information
Topotecan hydrochloride Diphenoxylate Haloperidol 2,2,6,6-Tetramethyl-4-piperidinol Triacetonediamine DROPERIDOL Piperazine Piperidinium acetate Bupivacaine hydrochloride (S)-3-Hydroxypiperidine hydrochloride (3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE HYDROCHLORIDE HEMIHYDRATE 3-AMINO-1-N-BOC-PIPERIDINE HYDROCHLORIDE,(+/-)-3-AMINO-1-N-BOC-PIPERIDINE HYDROCHLORIDE,3-AMINO-1-TERT-BUTOXYCARBONYL-PIPERIDINE HYDROCHLORIDE 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride (R)-3-Hydroxypiperidine hydrocloride (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride 4-(2,4-DIFLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE 1-(2-Chloroethyl)piperidine hydrochloride 4-Chloro-1-methylpiperidine hydrochloride