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Piperidine hydrochloride

Piperidine hydrochloride Basic information
Product Name:Piperidine hydrochloride
Synonyms:hexahydropyridinehydrochloride;PIPERIDINE HYDROCHLORIDE;PIPERIDINIUM CHLORIDE;PIPERIDINIUM HYDROCHLORIDE;PIPERIDINE HYDROCHLORIDE, CRYSTALLIZED;Piperidinehydrochloride,99%;Piperidiniumchlorid;PIPERIDINE HCL PIPERIDINE HYDROCHLORIDE
CAS:6091-44-7
MF:C5H11N.ClH
MW:121.61
EINECS:228-033-8
Product Categories:Piperidine;Building Blocks;Heterocyclic Building Blocks;Piperidines
Mol File:6091-44-7.mol
Piperidine hydrochloride Structure
Piperidine hydrochloride Chemical Properties
Melting point 245-248 °C(lit.)
Boiling point 347.05℃
density 1,12 g/cm3
vapor density 2.94 (vs air)
vapor pressure 63.6 mm Hg ( 37.8 °C)
Fp >230 °F
storage temp. Store below +30°C.
solubility >1500g/l
form Solid:crystalline
PH6-8 (111g/l, H2O, 20℃)
Water Solubility soluble
Sensitive Hygroscopic
BRN 3611699
InChIKeyVEIWYFRREFUNRC-UHFFFAOYSA-N
LogP-1.92
CAS DataBase Reference6091-44-7(CAS DataBase Reference)
EPA Substance Registry SystemPiperidine hydrochloride (6091-44-7)
Safety Information
Hazard Codes T
Risk Statements 25-37-36/37/38-23/24/25
Safety Statements 36/37/39-45-28A-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 1
RTECS TN0400000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29333200
MSDS Information
ProviderLanguage
Piperidine hydrochloride English
SigmaAldrich English
ACROS English
ALFA English
Piperidine hydrochloride Usage And Synthesis
Chemical PropertiesWHITE FINE CRYSTALLINE POWDER
UsesReagent for synthesis of:
  • Quinoline selenium compounds
  • Peripheral seratonin 5-HT3 receptor ligands

Reactant for synthesis of phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors

Reactant for:
  • Mannich reactions
  • Asymmetric hydrogenation of quinolines
  • Chemoselective reductive amination of carbonyl compounds
UsesPiperidine hydrochloride is used an intermediate in the manufacture of active pharmaceutical ingredients like anti Parkinsonan agent Biperiden; anti depressant agent Clocapramine hydrochloride and muscle relaxant tolperisone.
Purification MethodsCrystallise the salt from EtOH/diethyl ether in the presence of a small amount of HCl. [Beilstein 20 H 6, 20 II 10, 20 III/IV 295, 20/2 V 13.]
Piperidine hydrochloride Preparation Products And Raw materials
Preparation ProductsPiperidine-->Befunolol-->Bipariden-->3-(1-Piperidinyl)propiophenone HCl-->Diisopropylamine hydrochloride-->2-OXOBUTANALDEHYDE
Tag:Piperidine hydrochloride(6091-44-7) Related Product Information
Topotecan hydrochloride Diphenoxylate Haloperidol 2,2,6,6-Tetramethyl-4-piperidinol Triacetonediamine DROPERIDOL Piperazine Piperidinium acetate Bupivacaine hydrochloride (S)-3-Hydroxypiperidine hydrochloride (3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE HYDROCHLORIDE HEMIHYDRATE 3-AMINO-1-N-BOC-PIPERIDINE HYDROCHLORIDE,(+/-)-3-AMINO-1-N-BOC-PIPERIDINE HYDROCHLORIDE,3-AMINO-1-TERT-BUTOXYCARBONYL-PIPERIDINE HYDROCHLORIDE 1-Benzyl-4-cyano-4-phenylpiperidine hydrochloride (R)-3-Hydroxypiperidine hydrocloride (3s-trans)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride 4-(2,4-DIFLUOROBENZOYL)PIPERIDINE HYDROCHLORIDE 1-(2-Chloroethyl)piperidine hydrochloride 4-Chloro-1-methylpiperidine hydrochloride
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