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| | DL-4-Chlorophenylglycine Basic information |
| | DL-4-Chlorophenylglycine Chemical Properties |
| Melting point | 220-230°C | | Boiling point | 328.8±32.0 °C(Predicted) | | density | 1.392±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in 0.1mol/L NaOH (almost transparency). | | pka | 1.81±0.10(Predicted) | | form | Solid | | color | Off-white | | Major Application | peptide synthesis | | InChI | InChI=1S/C8H8ClNO2/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12) | | InChIKey | QGJGBYXRJVIYGA-UHFFFAOYSA-N | | SMILES | C(C1C=CC(Cl)=CC=1)(N)C(=O)O | | CAS DataBase Reference | 6212-33-5(CAS DataBase Reference) | | EPA Substance Registry System | Benzeneacetic acid, .alpha.-amino-4-chloro- (6212-33-5) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | TSCA listed | | HS Code | 2922.49.8000 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | DL-4-Chlorophenylglycine Usage And Synthesis |
| Chemical Properties | white to light yellow crystal powder | | Uses | It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis |
Ammonia and sodium hydroxide solution were placed in a container and cooled to 0C in an ice bath; under the condition of 0C in the container ice bath, sodium hydroxide solution was added to ammonia, and ammonia gas was passed through to produce a phase I solution; subsequently, the catalyst and p-chlorobenzaldehyde were added to chloroform, and the phase II solution was produced by oscillation; under the condition of the ice bath, phase I solution was added continuously to the phase II solution, and sodium saccharin was added at the same time; the container was transferred to the condition of the water bath , ammonium bicarbonate was added and allowed to stand after completion; the reaction was concentrated and p-chlorophenylglycine was precipitated.
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| | DL-4-Chlorophenylglycine Preparation Products And Raw materials |
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