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| | Carboxyatractyloside Basic information |
| Product Name: | Carboxyatractyloside | | Synonyms: | (2beta,15alpha)-15-Hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-beta-D-glucopyranosyl]oxy]kaur-16-ene-18,19-dioic acid;Carboxyatractyloside tripotassium salt;Kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-, (2β,15α)-;Carboxyatractylosidetripotassiumsal;Kaur-16-ene-18,19-dioic acid, 15-hydroxy-2-[[2-O-(3-methyl-1-oxobutyl)-3,4-di-O-sulfo-β-D-glucopyranosyl]oxy]-, (2β,15α)- | | CAS: | 77228-71-8 | | MF: | C31H46O18S2 | | MW: | 770.81 | | EINECS: | | | Product Categories: | reagent;standard substance;chemical reagent;herbal extract;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM). | | Mol File: | 77228-71-8.mol |  |
| | Carboxyatractyloside Chemical Properties |
| density | 1.58±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | H2O: ≥10mg/mL | | pka | -3?+-.0.18(Predicted) | | form | solid | | color | white |
| Hazard Codes | T | | Risk Statements | 23/24/25 | | Safety Statements | 36/37-45 | | RIDADR | UN 2811 6.1 / PGI | | WGK Germany | 3 |
| | Carboxyatractyloside Usage And Synthesis |
| Uses | Carboxyatractyloside potassium salt has been used as an activator of Ca2+-induced mPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) opening. It has also been used as a adenine nucleotide translocator (ANT) inhibitor to study the inhibition of oxidative phosphorylation in intact T98G glioma cells. | | Biochem/physiol Actions | Carboxyatractyloside is a highly selective inhibitor of cytosolic side-specific mitochondrial ADP/ATP carrier; i.e. adenine nucleotide translocase (ANT); causes stabilization of the c conformation of ANT leading to permeability transition pore (PTP) opening, loss of mitochondrial membrane potential, and apoptosis. | | target | Calcium Channel | P450 (e.g. CYP17) |
| | Carboxyatractyloside Preparation Products And Raw materials |
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