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Procaine hydrochloride

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CAS:51-05-8
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CAS:51-05-8
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CAS:51-05-8
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Products Intro: Product Name:Procain Hydrochloride
CAS:51-05-8
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Lastest Price from Procaine hydrochloride manufacturers

  • Procaine hydrochloride
  • US $1.00 / g
  • 2019-07-31
  • CAS:51-05-8
  • Min. Order: 10g
  • Purity: 99%
  • Supply Ability: 1000 Kilogram/Kilograms per Week
  • Procaine hydrochloride
  • US $1.00 / kg
  • 2019-07-06
  • CAS:51-05-8
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized

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Procaine hydrochloride Basic information
Local anesthetic
Product Name:Procaine hydrochloride
Synonyms:Procaine hcl powder;procaine hcl / hydrochloride;aminocaine;anadolor;anesthesol;anestil;Procaine Hydrochloride / Procaine HCl 51-05-8 local anesthesia;atoxicocaine
CAS:51-05-8
MF:C13H21ClN2O2
MW:272.77
EINECS:200-077-2
Product Categories:API-;Sodium channel;APIS;Anesthetics;Pharmaceutical intermediate;Pharmaceutical
Mol File:51-05-8.mol
Procaine hydrochloride Structure
Procaine hydrochloride Chemical Properties
Melting point 155-156 °C(lit.)
Boiling point 195-196°C 17mm
density 1.1761 (rough estimate)
refractive index 1.5270 (estimate)
Fp 195-196°C/17mm
storage temp. room temp
solubility Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
form Crystals or Crystalline Powder
color Colorless to white
Water Solubility soluble
Sensitive Air Sensitive
Merck 14,7757
BRN 3917802
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyHCBIBCJNVBAKAB-UHFFFAOYSA-N
CAS DataBase Reference51-05-8(CAS DataBase Reference)
EPA Substance Registry SystemProcaine hydrochloride (51-05-8)
Safety Information
Hazard Codes T
Risk Statements 25-43-36/37/38-23/24/25
Safety Statements 36/37/39-45-37/39-26
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DG2275000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29242990
ToxicityLD50 in mice (mg/kg): 660 ± 60 s.c. (Goldenthal)
MSDS Information
ProviderLanguage
Procaine hydrochloride English
SigmaAldrich English
ACROS English
ALFA English
Procaine hydrochloride Usage And Synthesis
Local anestheticProcaine hydrochloride is a topical anesthetic, which can block the nerve fiber conduction temporarilyand has a narcotic effect,strong effect, low toxicity, and non-addictive, but on the skin, mucosal penetration is weak, unsuitable for surface anesthesia, patients are used for infiltration, conduction and spinal anesthesia.
White fine needle crystal or crystalline powder at room temperature, no smell, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Procaine hydrochloride ester bond structure can be hydrolyzed to produce amino acid and diethylaminoethanol, under certain conditions, the amino acid may be further decarboxylated toxic aniline.
The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0~5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.
The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β-naphthol, generating azo compounds scarlet.
The above information is edited by the chemicalbook of Kui Xiongfeng.
Chemical PropertiesSmall, colorless crystals or white, crys- talline powder; odorless; stable in air. Soluble in water and in alcohol at 25C; slightly soluble in chloroform; almost insoluble in ether; solutions acid to litmus.
UsesLocal anesthesic;Na+ channel blocker
UsesProcaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.
UsesNon Caine local anesthetic.
UsesA sodium channel blocker and DNA methylation inhibitor
Brand nameNovocain (Hospira).
HazardToxic by ingestion.
Contact allergensProcaine is a local anesthetic with para-amino function. Sensitization mainly concerns the medical, dental, and veterinary professions.
Safety ProfilePoison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects: acute renal fdure. May have human reproductive effects. See also ESTERS. When heated to decomposition it emits very toxic fumes of HCl and NO,. Used as a local anesthetic.
Purification MethodsNovocain is recrystallised from aqueous EtOH. It is soluble at 25o in H2O (86.3%), EtOH (2.6%) and Me2CO (1%), it is slightly soluble in CHCl3, but is almost insoluble in Et2O. The anhydrous free base is recrystallised from ligroin or Et2O and has m 61o. [Einhorn Justus Liebigs Ann Chem 371 125 1909, IR: Szymanski & Panzica J Amer Pharm Assoc 47 443 1958, Beilstein 14 IV 1138.]
Procaine hydrochloride Preparation Products And Raw materials
Preparation ProductsProcaine penicillin G
Raw materialsDiethylamine-->p-Nitrobenzoic acid
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