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Methyl chloroformate

Methyl chloroformate Basic information
Product Name:Methyl chloroformate
Synonyms:Carbonochlorididicacidmethylester;Chlorameisensaeure methylester;chlorameisensaeuremethylester;Chlorocarbonate de methyle;chlorocarbonatedemethyle;chlorocarbonatedemethyle(french);Chlorocarbonic acid, methyl ester;chlorocarbonicacidmethylester
Product Categories:Organics;CHLOROFORMATES;Acid HalidesDerivatization Reagents HPLC;Carbonyl Chlorides;Carbonyl Compounds;Fluorescence;Organic Building Blocks;API Intermediate;Miscellaneous Reagents
Mol File:79-22-1.mol
Methyl chloroformate Structure
Methyl chloroformate Chemical Properties
Melting point -61°C
Boiling point 70-72 °C(lit.)
density 1.223 g/mL at 25 °C(lit.)
vapor density 3.26 (vs air)
vapor pressure 4.8 psi ( 20 °C)
refractive index n20/D 1.387(lit.)
Fp 64 °F
storage temp. Store at 0-5°C
form Liquid
color Clear colorless to light yellow
Water Solubility hydrolysis
Merck 13,6071
CAS DataBase Reference79-22-1(CAS DataBase Reference)
NIST Chemistry ReferenceCarbonochloridic acid, methyl ester(79-22-1)
EPA Substance Registry SystemCarbonochloridic acid, methyl ester(79-22-1)
Safety Information
Hazard Codes F,T+
Risk Statements 11-21/22-26-34
Safety Statements 14-26-28-36/37/39-45-63-46-28A-39-36/37
RIDADR UN 1238 6.1/PG 1
WGK Germany 2
RTECS FG3675000
HazardClass 6.1(a)
PackingGroup I
Hazardous Substances Data79-22-1(Hazardous Substances Data)
MSDS Information
SigmaAldrich English
Methyl chloroformate Usage And Synthesis
Chemical PropertiesColorless liquid
UsesChloroformic Acid Methyl Ester is used in the synthesis of a new class of potent Cdk4 inhibitors in the treatment of cancer. Also used in the synthesis of Phorboxazole B.
General DescriptionA colorless liquid with a pungent odor. Flash point 54°F. Corrosive to metals and tissue. Vapors heavier than air. Very toxic by inhalation. Used to make other chemicals and insecticides.
Air & Water ReactionsHighly flammable. Gives off hydrochloric acid fumes in contact with moist air. Slightly soluble in water and decomposed by water to hydrochloric acid with evolution of heat.
Reactivity ProfileMethyl chloroformate is incompatible with water, strong oxidizing agents, alcohols, bases (including amines). Decomposes slowly in water to yield methanol, HCl, and CO2; reaction can be hazardous if water is hot. Attacks many metals especially in humid atmosphere [Handling Chemicals Safely 1980. p. 476]. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health HazardMethyl chloroformate is highly toxic upon inhalation and upon ingestion. A concentration of 1 mg/liter (190 ppm) has been lethal in 10 minutes. It is corrosive and irritating to skin.
Fire HazardMethyl chloroformate is very dangerous when exposed to heat sources, sparks, flame, or oxidizers. Methyl chloroformate will react with water or steam to produce toxic and corrosive fumes. Vapors may travel to a source of ignition and flash back. Withdraw immediately in case of rising sound from venting safety device or any discoloration of tank due to fire. Toxic fumes of phosgene are produced when the material is heated to decomposition. Heat or steam should be avoided.
Tag:Methyl chloroformate(79-22-1) Related Product Information
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