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FLUOROACETAMIDE Basic information
Synonyms:1081;2-fluoro-acetamid;acetamide,2-fluoro;AFL 1081;afl1081;Amid kyseliny fluoroctove;amidkyselinyfluoroctove;rcrawastenumberp057
Product Categories:Amides;Carbonyl Compounds;Organic Building Blocks
Mol File:640-19-7.mol
FLUOROACETAMIDE Chemical Properties
Melting point 106-108 °C(lit.)
Boiling point 259.0±10.0 °C(Predicted)
density 1.1170 (estimate)
Merck 13,4193
BRN 1739054
CAS DataBase Reference640-19-7(CAS DataBase Reference)
EPA Substance Registry SystemFluoroacetamide (640-19-7)
Safety Information
Hazard Codes T+,T,Xi
Risk Statements 24-28
Safety Statements 36/37-45
RIDADR UN 2811 6.1/PG 2
WGK Germany 2
RTECS AC1225000
Hazard Note Highly Toxic/Irritant
HazardClass 6.1(a)
PackingGroup I
HS Code 29241200
Hazardous Substances Data640-19-7(Hazardous Substances Data)
ToxicityLD50 i.p. in mice: 85 mg/kg (Matsumura, O'Brien)
MSDS Information
SigmaAldrich English
DescriptionFluoroacetamide is an odourless, tasteless, white, crystalline water soluble. It is a fluorinated amide and reacts with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Fluoroacetamide is used as a rodenticide and insecticide to control rabbits but is dangerous for other species of pests, farm livestock, and humans. Fluoroacetamide is a noncombustible substance itself and does not burn but may decompose upon heating to produce irritating, corrosive, and/or toxic fumes. On decomposition, fluoroacetamide releases nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide, HF gas, and nitrogen gas.
Chemical Propertiescrystals
Chemical PropertiesFluoroacetamide is a colorless, crystalline solid.
UsesRodenticide. Insecticide proposed mainly for use on fruits to combat scale insects, aphids, and mites.
DefinitionChEBI: Acetamide substituted at C-2 by a fluorine atom.
Production MethodsFluoroacetamide is produced by reaction of α-chloroacetamide with potassium fluoride in tetrachloroethylene at elevated temperature.
General DescriptionColorless crystalline powder. Used as a rodenticide. Highly toxic.
Air & Water ReactionsVery soluble in water [Farm Chemicals]
Reactivity ProfileFLUOROACETAMIDE is a fluorinated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).
HazardExtremely toxic; poison; mutagen.
Health HazardFLUOROACETAMIDE is super toxic; probable oral lethal dose in humans is less than 5 mg/kg, or a taste (less than 7 drops) for a 150-lb. person. Chemically inhibits oxygen metabolism by cells with critical damage occurring to the heart, brain, and lungs resulting in heart failure, respiratory arrest, convulsions, and death.
Fire HazardEmits very toxic fumes of fluorine containing compounds and nitrogen oxides when heated to decomposition. Avoid decomposing heat.
Safety ProfileA human poison by an unspecified route. Poison experimentally by ingestion, skin contact, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by unspecified route: convulsions, coma, nausea and vomiting. Experimental reproductive effects. Mutation data reported. Used as an insecticide and rodenticide. When heated to decomposition it emits very toxic fumes of Fand NOx. See also FLUORIDES.
Potential ExposureThis material is an organofluorine rodenticide; insecticide proposed mainly for use on fruits to combat scale insects, aphids, and mites. Use is largely restricted to licensed pest control operators.
ShippingUN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification MethodsCrystallise fluoroacetamide from chloroform and dry it in a vacuum. [Beilstein 2 IV 454.]
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo sions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste DisposalConsult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations govern ing storage, transportation, treatment, and waste disposal.
FLUOROACETAMIDE Preparation Products And Raw materials
Raw materialsTetrachloroethylene-->Chloroacetamide-->Methyl fluoroacetate-->Fluoroacetonitrile-->FLUOROACETYL CHLORIDE-->Cyclohexene-->Ethyl fluoroacetate-->Ethyl diazoacetate
Tag:FLUOROACETAMIDE(640-19-7) Related Product Information
N-METHYL 2-BROMO-2-FLUOROACETAMIDE 2-Iodo-2-fluoroacetamide N1,N1-Diethyl-2-chloro-2-fluoroacetamide,2-Chloro-N,N-diethyl-2-fluoroacetamide N-(4-Chlorophenyl)-2-fluoroacetamide N,N-Dimethyl-2-phenyl-2-fluoroacetamide N,O-BIS(TRIFLUOROACETYL)HYDROXYLAMINE N-(TERT-BUTYLDIMETHYLSILYL)-N-METHYL-TRI FLUOROACETAMIDE, 97+% N-Methyl-2,2,2-trifluoroacetamide (S)-(-)-2-(TRIFLUOROACETAMIDO)SUCCINIC ANHYDRIDE N-Heptafluorobutyrylimidazole (S)-(-)-N-(TRIFLUOROACETYL)PROLYL CHLORIDE N10-(TRIFLUOROACETYL)PTEROIC ACID Tegafur 2-TRIFLUOROACETAMIDO-7-NITROFLUORENE Trifluoroacetamide 1-(Trifluoroacetyl)imidazole 1-(PENTAFLUOROPROPIONYL)IMIDAZOLE HEXAFLUOROGLUTARAMIDE