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Fludarabine phosphate

Fludarabine phosphate Suppliers list
Company Name: Beijing Yibai Biotechnology Co., Ltd
Tel: 0086-182-6772-3597
Email: sales04@yibaibiotech.com
Products Intro: Product Name:Fludarabine Phosphate
CAS:75607-67-9
Purity:99 Package:100g;0USD|500g;0USD|1KG;0USD|5KG;0USD|25KG;0USD
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-571-85586718 +86(0)13336195806
Email: sales@capotchem.com
Products Intro: Product Name:Fluclarabine phosphate
CAS:75607-67-9
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-66670886
Email: info@dakenchem.com
Products Intro: Product Name:Fludarabine phosphate
CAS:75607-67-9
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: Product Name:Fludarabine phosphate
CAS:75607-67-9
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 008615858145714
Email: fandachem@gmail.com
Products Intro: Product Name:Fludarabine phosphate fandachem
CAS:75607-67-9
Purity:As coa Package:As request Remarks:75607-67-9

Fludarabine phosphate manufacturers

  • Fludarabine Phosphate
  • $2.70 / g/Bag
  • 2021-12-01
  • CAS:75607-67-9
  • Min. Order: 10g
  • Purity: 99.7%
  • Supply Ability: 10000kg
  • Fludarabine phosphate
  • $5.00 / KG
  • 2021-11-08
  • CAS:75607-67-9
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100 Tons
  • Fludarabine phosphate
  • $15.00-10.00 / KG
  • 2021-07-13
  • CAS:75607-67-9
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Fludarabine phosphate Basic information
Product Name:Fludarabine phosphate
Synonyms:Fludarabine (NSC-118218) phosphate;2-fluoro-9-(5-o-phosphono-beta-d-arabinofuranosyl)-9h-purin-6-amine;2-fluoro-araamp;9-beta-arabinofuranosyl-2-fluoroadenine-5’-phosphate;5-Monophosphate;Fludarabine phosphate 75607-67-9;9-BETA-D-ARABINOFURANOSYL-2-FLUOROADENINE-5'-DIHYDROGEN PHOSPHATE;FLUDARUBINE PHOSPHATE
CAS:75607-67-9
MF:C10H13FN5O7P
MW:365.21
EINECS:616-242-0
Product Categories:Inhibitors;Anti-cancer&immunity;Active Pharmaceutical Ingredients;Antineoplastics;Antineoplastic;API
Mol File:75607-67-9.mol
Fludarabine phosphate Structure
Fludarabine phosphate Chemical Properties
Melting point 203°C(dec.)(lit.)
alpha [α]D20 +10~+14゜(c=0.5,H2O)
Boiling point 864.2±75.0 °C(Predicted)
density 2.39±0.1 g/cm3(Predicted)
RTECS UO7440900
storage temp. 2-8°C
solubility DMSO: soluble1mg/mL
pka1.86±0.10(Predicted)
form Powder
color white
Water Solubility Soluble in DMSO or water at 5mg/ml
Merck 14,4126
InChIKeyGIUYCYHIANZCFB-GFRUICAKSA-N
CAS DataBase Reference75607-67-9(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 2934990002
MSDS Information
Fludarabine phosphate Usage And Synthesis
DescriptionFludarabine phosphate is an antimetabolite indicated for the treatment of B cell lymphocytic leukemia. It is reportedly effective in patients refractory to other therapies. Fludarabine phosphate acts by inhibiting primer RNA synthesis. Its side effects include bone marrow suppression, anemia, thrombocytopenia and neutropenia.
Chemical PropertiesWhite or almost white, crystalline powder, hygroscopic.
OriginatorSouthern Research Institute (U.S.A.)
Usesanticonvulsant
DefinitionChEBI: A purine arabinonucleoside monophosphate having 2-fluoroadenine as the nucleobase. A prodrug, it is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. Onc incorporated into DNA, 2-fluoro-ara-ATP functions as a DNA chain terminator. It is used for the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to, or whose disease has progressed during, treatment with at least one standard alkylating-agent containing regimenas.
Brand nameFludara (Berlex).
PharmacologyFludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Phase I studies in humans have demonstrated that fludarabine phosphate is rapidly converted to the active metabolite, 2-fluoro-ara-A, within minutes after intravenous infusion.
Consequently, clinical pharmacology studies have focused on 2-fluoro-ara-A pharmacokinetics. After the five daily doses of 25 mg 2-fluoro-ara-AMP/m2 to cancer patients infused over 30 minutes, 2-fluoro-ara-A concentrations show a moderate accumulation. During a 5-day treatment schedule, 2-fluoro-ara-A plasma trough levels increased by a factor of about 2. The terminal half-life of 2-fluoro-ara-A was estimated as approximately 20 hours. In vitro, plasma protein binding of fludarabine ranged between 19% and 29%.
Clinical UseFludarabine phosphate (Fludara ® ), is a fluorinated nucleotide analog of the antiviral agent vidarabine, 9-β-D-arabinofuranosyladenine(ara-A), which differs only by the presence of a fluorine atom at position 2 of the purine moiety and a phosphate group at position 5 of the arabinose moiety (Plunkett et al., 1993). These structural modifications result in increased aqueous solubility and resistance to enzymatic degradation by adenosine deaminases compared to vidarabine (Brockman et al., 1977; Plunkett et al., 1990). Fludarabine phosphate is indicated for the treatment of patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating agent containing regimen (Boogaerts et al., 2001; Rossi et al., 2004).
Fludarabine phosphate Preparation Products And Raw materials
Tag:Fludarabine phosphate(75607-67-9) Related Product Information
Temozolomide Gemcitabine hydrochloride Milrinone Fludarabine 2-Fluoroadenine 5'-Adenylic acid, 2-amino- Inosine, 2-fluoro- beta-D-Arabinofuranose (9CI) Fludarabine Phosphate EP Impurity A Fludarabine Phosphate iMpurity B Fludarabine Phosphate iMpurity F Fludarabine Phosphate EP Impurity C Intermediate of fludarabine phosphate FLUDARABINE PHOSPHATE''S INTERMEDIATES Vidarabine monophosphate 2-FLUOROADENINE-BETA-D-ARABINOFURANOSIDE 5'-MONOPHOSPHATE, DIAMMONIUM SALT, [8-3H]- Vidarabine 6-BENZYLOXYAMINO-9-(5-O-DIPHENYLPHOSPHONO-BETA-D-ARABINOFURANOSYL)-2-FLUORO-9H-PURINE