- (R)-3-Hydroxypyrrolidine
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- $34.00 / 1kg
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2024-04-08
- CAS:2799-21-5
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | (R)-3-Hydroxypyrrolidine Basic information |
| | (R)-3-Hydroxypyrrolidine Chemical Properties |
| Melting point | 15°C | | Boiling point | 215-216 °C (lit.) | | alpha | 6.5 º (c=3.5% in MeOH) | | density | 1.078 g/mL at 20 °C (lit.) | | refractive index | n20/D 1.488(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | pka | 14.91±0.20(Predicted) | | form | Viscous Liquid | | color | Clear yellow to orange-brown | | Specific Gravity | 1.048 | | optical activity | [α]20/D +6.5°, c = 3.5 in methanol | | Water Solubility | Soluble in water and methanol. | | Sensitive | Air Sensitive & Hygroscopic | | BRN | 5376132 | | CAS DataBase Reference | 2799-21-5(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | F | 10-34 | | Hazard Note | Irritant | | HS Code | 29339900 |
| | (R)-3-Hydroxypyrrolidine Usage And Synthesis |
| Chemical Properties | clear yellow to orange-brown viscous liquid | | Uses | (R)-Pyrrolidin-3-ol is used in preparation of allosteric BCR-ABL bifunctional proteolysis targeting chimera compounds. | | Purification Methods | The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.] |
| | (R)-3-Hydroxypyrrolidine Preparation Products And Raw materials |
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