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| | Potassium bis(trimethylsilyl)amide Basic information |
| | Potassium bis(trimethylsilyl)amide Chemical Properties |
| Melting point | 194-195°C | | Boiling point | 111 °C | | density | 0.877 g/mL at 25 °C | | vapor density | 3.2 (vs air) | | vapor pressure | 54 mm Hg ( 25 °C) | | refractive index | 1.4920 | | Fp | 45 °F | | storage temp. | Refrigerator | | solubility | Miscible with terahydrofuran, ether, benzene and toluene. | | form | Liquid | | Specific Gravity | 0.877 | | color | clear to slightly hazy yellow | | Water Solubility | Reacts with water. | | Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents | | Sensitive | Moisture Sensitive | | BRN | 4006754 | | CAS DataBase Reference | 40949-94-8(CAS DataBase Reference) | | EPA Substance Registry System | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8) |
| | Potassium bis(trimethylsilyl)amide Usage And Synthesis |
| Chemical Properties | Colorless to amber solution | | Uses | Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates. | | Uses | Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions. | | Uses | Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1 | | Preparation | Potassium Hexamethyldisilazide is prepared and isolated by the procedure
of Wannagat and Niederpruem. A more convenient in situ
generation from potassium hydride and hexamethyldisilane is
described by Brown. | | General Description | This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention". |
| | Potassium bis(trimethylsilyl)amide Preparation Products And Raw materials |
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