Silane reagent

Silane reagent refers to a class of organic silicon monomer or small molecule compounds in organic synthesis or analysis or for the protection of organic change in the active group. After the reaction of the silane groups falling restitution. There are more than 500 species, including:
(1) The trimethylsilyl group the SBA monofunctional, e.g. trimethylchlorosilane, bis (trimethylsilyl) amine and the like.
(2) the SBA monoenergetic sterically hindered, such as tert-butyldimethylsilyl chloride, triisopropyl chloro silane.
(3) the SBA difunctional sterically hindered, such as dimethyl acetoxy silane, di-t-butyl dichloro silane.
(4) Other protective agent, such as trimethyl silane-hydroxyethyl, hydroxyethyl methyl diphenyl silane.

Silane reagent can be used to analyze the field of organic synthesis (eg pharmaceutical synthesis). Modified drugs may also be used, such as to make it oil-soluble or loss of bitterness and the like.

Refers to the effect of silylation silyl group introduced into the molecule, usually an active hydrogen-substituted (eg: hydroxyl -OH, carboxyl groups -COOH, -NH2 in an amino group, a mercapto group -SH, phosphate). After the active hydrogen group substituted with a silane reducing polar compounds, to reduce the hydrogen bondage, silylated derivative thus formed is more volatile; Meanwhile, due to the reduced number of reactive sites of the active hydrogen-containing, but also stability of the compound can be strengthened. Silane compounds polar weakened, the measured capacity enhancement, improved thermal stability. Silylating agent in GC analysis uses a great many considered to be non-volatile or thermally unstable at 200-300 ℃ hydroxy or amino compounds successfully conducted chromatography after silylation.

It is precisely because the silane reagent to active hydrogen sensitive, reactive therewith happen, so the same silylating agent is very sensitive to moisture, water in the environment itself decomposition failure. Usually mentioned silylating agent, are sealed in nitrogen. Nitrogen must be pre-dried to remove water. After access to the silylating agent, again before the seal must charge into nitrogen. So that you can get rid of the air, to avoid the seal into the air so that the period of contact with moisture in the air with the silylating agent. Nitrogen filling method Proceed as follows: Connect a nitrogen cylinder with a Teflon tube at one end, connected at one end Pasteur pipette. The straw into his head to be filled with nitrogen silane reagent bottle from the reagent liquid silane of about 2 ~ 3cm. Open the nitrogen switch, so that nitrogen slowly into the vial until it has been filled with nitrogen, silane reagent bottle of white space. Removed the straw and immediately sealed tight bottle, close nitrogen.

Trimethylsilyl imidazole silane is strongest hydroxy silylating agent; quickly, smoothly and carboxyl groups react with hydroxyl groups. Does not react with amines or amides, it can be used to prepare both a hydroxy and an amino derivative containing multiple compounds. In the presence of a small amount of water it can be used silane sugar; when you need to analyze the sugar syrup as the sugar is ideal for silylation. Derivatives can not be hindered and the most serious impediment to steroid hydroxyl groups.

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Structure Chemical Name CAS MF
N-Methyl-N-(trimethylsilyl)trifluoroacetamide N-Methyl-N-(trimethylsilyl)trifluoroacetamide 24589-78-4 C6H12F3NOSi
Methyltris(methylethylketoxime)silane Methyltris(methylethylketoxime)silane 22984-54-9 C13H27N3O3Si
Heptamethyldisilazane Heptamethyldisilazane 920-68-3 C7H21NSi2
(3-Glycidyloxypropyl)triethoxysilane (3-Glycidyloxypropyl)triethoxysilane 2602-34-8 C12H26O5Si
Bis(triethoxysilylpropyl) disulfide Bis(triethoxysilylpropyl) disulfide 56706-10-6 C18H42O6S2Si2
2-(Trimethylsilyl)pyridine 2-(Trimethylsilyl)pyridine 13737-04-7 C8H13NSi
3-Chloropropyltrichlorosilane 3-Chloropropyltrichlorosilane 2550-06-3 C3H6Cl4Si
Bis[3-(triethoxysilyl)propyl]tetrasulfide Bis[3-(triethoxysilyl)propyl]tetrasulfide 40372-72-3 C18H42O6S4Si2
Silica glass Silica glass 60676-86-0 O2Si
1-(TRIISOPROPYLSILYL)PYRROLE 1-(TRIISOPROPYLSILYL)PYRROLE 87630-35-1 C13H25NSi
2-(Trimethylsilyl)ethoxymethyl chloride 2-(Trimethylsilyl)ethoxymethyl chloride 76513-69-4 C6H15ClOSi
1,2-BIS(TRIMETHOXYSILYL)ETHANE 1,2-BIS(TRIMETHOXYSILYL)ETHANE 18406-41-2 C8H22O6Si2
N-Methylaminopropyltrimethoxysilane N-Methylaminopropyltrimethoxysilane 3069-25-8 C7H19NO3Si
(3,3,3-Trifluoropropyl)dichloromethylsilane (3,3,3-Trifluoropropyl)dichloromethylsilane 675-62-7 C4H7Cl2F3Si
2-THIENYLTRIMETHYLSILANE 2-THIENYLTRIMETHYLSILANE 18245-28-8 C7H12SSi
2-(Trimethylsilyl)thiazole 2-(Trimethylsilyl)thiazole 79265-30-8 C6H11NSSi
Vinyltris(methylethylketoxime)silane Vinyltris(methylethylketoxime)silane 2224-33-1 C14H27N3O3Si
Dichloromethylphenylsilane Dichloromethylphenylsilane 149-74-6 C7H8Cl2Si
TRIPHENYLFLUOROSILANE TRIPHENYLFLUOROSILANE 379-50-0 C18H15FSi
Tributylchlorosilane Tributylchlorosilane 995-45-9 C12H27ClSi
1-TRIMETHYLSILYL-1,2,4-TRIAZOLE 1-TRIMETHYLSILYL-1,2,4-TRIAZOLE 18293-54-4 C5H11N3Si
3-(TRIMETHYLSILYL)-1-PROPANESULFONIC ACID SODIUM SALT 3-(TRIMETHYLSILYL)-1-PROPANESULFONIC ACID SODIUM SALT 2039-96-5 C6H15NaO3SSi
1,2-BIS(TRICHLOROSILYL)ETHANE 1,2-BIS(TRICHLOROSILYL)ETHANE 2504-64-5 C2H4Cl6Si2
N-(Trimethylsilyl)imidazole N-(Trimethylsilyl)imidazole 18156-74-6 C6H12N2Si
4-TRIMETHYLSILYL-3-BUTYN-2-OL 4-TRIMETHYLSILYL-3-BUTYN-2-OL 6999-19-5 C7H14OSi
Triethoxypropylsilane Triethoxypropylsilane 2550-02-9 C9H22O3Si
Trimethoxyoctylsilane Trimethoxyoctylsilane 3069-40-7 C11H26O3Si
1,3-Bis(trimethylsilyl)urea 1,3-Bis(trimethylsilyl)urea 18297-63-7 C7H20N2OSi2
(N,N-Diethyl-3-aminopropyl)trimethoxysilane (N,N-Diethyl-3-aminopropyl)trimethoxysilane 41051-80-3 C10H25NO3Si
Isobutyltrimethoxysilane Isobutyltrimethoxysilane 18395-30-7 C7H18O3Si
N-[(Trimethylsilyl)methyl]benzylamine N-[(Trimethylsilyl)methyl]benzylamine 53215-95-5 C11H19NSi
Potassium trimethylsilanolate Potassium trimethylsilanolate 10519-96-7 C3H9KOSi
BIS(CHLOROMETHYL)DIMETHYLSILANE BIS(CHLOROMETHYL)DIMETHYLSILANE 2917-46-6 C4H10Cl2Si
4-(Trimethylsilyl)morpholine 4-(Trimethylsilyl)morpholine 13368-42-8 C7H17NOSi
(BROMOMETHYL)TRIMETHYLSILANE (BROMOMETHYL)TRIMETHYLSILANE 18243-41-9 C4H11BrSi
2,4-Dichlorobenzoyl peroxide 2,4-Dichlorobenzoyl peroxide 133-14-2 C14H6Cl4O4
PHENYLDICHLOROSILANE PHENYLDICHLOROSILANE 1631-84-1 C6H6Cl2Si
N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide 77377-52-7 C9H18F3NOSi
Diisodecyl phthalate Diisodecyl phthalate 26761-40-0 C28H46O4
1,1,3,3-TETRAMETHYLDISILAZANE 1,1,3,3-TETRAMETHYLDISILAZANE 15933-59-2 C4H15NSi2
Fiber Glass Wool Fiber Glass Wool 65997-17-3 CaNaO4P
Potassium bis(trimethylsilyl)amide Potassium bis(trimethylsilyl)amide 40949-94-8 C6H18KNSi2
Dicumyl peroxide Dicumyl peroxide 80-43-3 C18H22O2
3-Methacryloxypropylmethyldimethoxysilane 3-Methacryloxypropylmethyldimethoxysilane 14513-34-9 C10H20O4Si
Phenyltris(dimethylsiloxy)silane Phenyltris(dimethylsiloxy)silane 18027-45-7 C12H26O3Si4
3-[2-(2-Aminoethylamino)ethylamino]propyl-trimethoxysilane 3-[2-(2-Aminoethylamino)ethylamino]propyl-trimethoxysilane 35141-30-1 C10H27N3O3Si
HEXADECYLTRIMETHOXYSILANE HEXADECYLTRIMETHOXYSILANE 16415-12-6 C19H42O3Si
TRIMETHYLFLUOROSILANE TRIMETHYLFLUOROSILANE 420-56-4 C3H9FSi
Dichlorosilane Dichlorosilane 4109-96-0 Cl2H2Si
Bis[3-(triethoxysilyl)propyl]amine Bis[3-(triethoxysilyl)propyl]amine 13497-18-2 C18H43NO6Si2
DI-TERT-BUTYLSILANE DI-TERT-BUTYLSILANE 30736-07-3 C8H20Si
DIISOPROPYLCHLOROSILANE DIISOPROPYLCHLOROSILANE 2227-29-4 C6H15ClSi
Triethoxyisobutylsilane Triethoxyisobutylsilane 17980-47-1 C10H24O3Si
Celite Celite 61790-53-2 O2Si
Chloromethyltrimethoxysilane Chloromethyltrimethoxysilane 5926-26-1 C4H11ClO3Si
MOLECULAR SIEVES PACK 4A MOLECULAR SIEVES PACK 4A 70955-01-0 C20H25FN2O8
3-IODOPROPYLTRIMETHOXYSILANE 3-IODOPROPYLTRIMETHOXYSILANE 14867-28-8 C6H15IO3Si
Benzylchlorodimethylsilane Benzylchlorodimethylsilane 1833-31-4 C9H13ClSi
3-Isocyanatopropyltrimethoxysilane 3-Isocyanatopropyltrimethoxysilane 15396-00-6 C7H15NO4Si
T-BUTYLDIMETHYLSILANE T-BUTYLDIMETHYLSILANE 29681-57-0 C6H16Si
(METHOXYMETHYL)TRIMETHYLSILANE (METHOXYMETHYL)TRIMETHYLSILANE 14704-14-4 C5H14OSi
1-PHENYL-2-(TRIMETHYLSILYL)ACETYLENE 1-PHENYL-2-(TRIMETHYLSILYL)ACETYLENE 2170-06-1 C11H14Si
DIVINYLDIMETHYLSILANE DIVINYLDIMETHYLSILANE 10519-87-6 C6H12Si
1,1,3,3-TETRAISOPROPYLDISILOXANE 1,1,3,3-TETRAISOPROPYLDISILOXANE 18043-71-5 C12H30OSi2
1-CHLOROETHYLTRIMETHYLSILANE 1-CHLOROETHYLTRIMETHYLSILANE 7787-87-3 C5H13ClSi
3-Butenyltrimethylsilane 3-Butenyltrimethylsilane 763-13-3 C7H16Si
Diisobutyldimethoxysilane Diisobutyldimethoxysilane 17980-32-4 C10H24O2Si
(Trimethylsilyl)methylamine (Trimethylsilyl)methylamine 18166-02-4 C4H13NSi
PHENYLDIMETHYLETHOXYSILANE PHENYLDIMETHYLETHOXYSILANE 1825-58-7 C10H16OSi
Methyltris(trimethylsiloxy)silane Methyltris(trimethylsiloxy)silane 17928-28-8 C10H30O3Si4
DI-N-BUTYLDICHLOROSILANE DI-N-BUTYLDICHLOROSILANE 3449-28-3 C8H18Cl2Si
SILICON TETRABROMIDE SILICON TETRABROMIDE 7789-66-4 Br4Si
TERT-BUTYLDIMETHYLSILYLIMIDAZOLE TERT-BUTYLDIMETHYLSILYLIMIDAZOLE 54925-64-3 C9H18N2Si
DIPHENYLCHLOROSILANE DIPHENYLCHLOROSILANE 1631-83-0 C12H11ClSi
3-(TRIMETHYLSILYL)PROPIOLIC ACID 3-(TRIMETHYLSILYL)PROPIOLIC ACID 5683-31-8 C6H10O2Si
N-DECYLMETHYLDICHLOROSILANE N-DECYLMETHYLDICHLOROSILANE 18051-88-2 C11H24Cl2Si
SODIUM TRIMETHYLSILANOLATE SODIUM TRIMETHYLSILANOLATE 18027-10-6 C3H9NaOSi
N-BUTYLTRIMETHOXYSILANE N-BUTYLTRIMETHOXYSILANE 1067-57-8 C7H18O3Si
DIMETHOXYMETHYL-N-OCTADECYLSILANE DIMETHOXYMETHYL-N-OCTADECYLSILANE 70851-50-2 C21H46O2Si
BIS[3-(TRIMETHOXYSILYL)PROPYL]ETHYLENE DIAMINE BIS[3-(TRIMETHOXYSILYL)PROPYL]ETHYLENE DIAMINE 68845-16-9 C14H36N2O6Si2
4-(TRIMETHYLSILOXY)BENZALDEHYDE 4-(TRIMETHYLSILOXY)BENZALDEHYDE 1012-12-0 C10H14O2Si
1H,1H,2H,2H-PERFLUORODECYLMETHYLDICHLOROSILANE 1H,1H,2H,2H-PERFLUORODECYLMETHYLDICHLOROSILANE 3102-79-2 C11H7Cl2F17Si
Trichloro(3,3,3-trifluoropropyl)silane Trichloro(3,3,3-trifluoropropyl)silane 592-09-6 C3H4Cl3F3Si
3-Thiocyanatopropyltriethoxysilane 3-Thiocyanatopropyltriethoxysilane 34708-08-2 C10H21NO3SSi
SILICOTUNGSTIC ACID HYDRATE SILICOTUNGSTIC ACID HYDRATE 12027-38-2 H6O41SiW12
Vinyl tris(trimethylsiloxy)silane Vinyl tris(trimethylsiloxy)silane 5356-84-3 C11H30O3Si4
1-Trimethylsilyl-1-hexyne 1-Trimethylsilyl-1-hexyne 3844-94-8 C9H18Si
DIALLYLDIMETHYLSILANE DIALLYLDIMETHYLSILANE 1113-12-8 C8H16Si
(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE (3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE 89031-84-5 C9H21BrOSi
Tetra-(methylethylketoxime)silane Tetra-(methylethylketoxime)silane 34206-40-1 C16H32N4O4Si
1H,1H,2H,2H-PERFLUORODECYLTRIETHOXYSILANE 1H,1H,2H,2H-PERFLUORODECYLTRIETHOXYSILANE 101947-16-4 C16H19F17O3Si
ETHYLMETHYLDICHLOROSILANE ETHYLMETHYLDICHLOROSILANE 4525-44-4 C3H8Cl2Si
1H,1H,2H,2H-PERFLUOROOCTYLMETHYLDICHLOROSILANE 1H,1H,2H,2H-PERFLUOROOCTYLMETHYLDICHLOROSILANE 73609-36-6 C9H7Cl2F13Si
(3,3,3-TRIFLUOROPROPYL)METHYLDIMETHOXYSILANE (3,3,3-TRIFLUOROPROPYL)METHYLDIMETHOXYSILANE 358-67-8 C6H13F3O2Si
SILICON TETRAACETATE SILICON TETRAACETATE 562-90-3 C8H12O8Si
Tri(isopropoxy)vinylsilane Tri(isopropoxy)vinylsilane 18023-33-1 C11H24O3Si
DIATOMACEOUS EARTH DIATOMACEOUS EARTH 68855-54-9 O2 Si
HEXYLTRICHLOROSILANE HEXYLTRICHLOROSILANE 928-65-4 C6H13Cl3Si
3-Chloropropylmethyldichlorosilane 3-Chloropropylmethyldichlorosilane 7787-93-1 C4H9Cl3Si
MOLECULAR SIEVE MOLECULAR SIEVE 63231-69-6 AlCaNaO9Si3
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