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Bisoprolol

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Products Intro: Product Name:Bisoprolol
CAS:66722-44-9
Purity:99% Package:1kg;2USD
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Products Intro: CAS:66722-44-9
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Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:bisoprolol
CAS:66722-44-9
Purity:99% Package:5KG;1KG Remarks:C18H31NO4
Company Name: Chongqing Chemdad Co., Ltd
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Products Intro: Product Name:Bisoprolol
CAS:66722-44-9
Purity:0.98 Package:1kg,2kg,5kg,10kg,25kg
Company Name: HENAN BON INDUSTRIAL CO.,LTD
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Products Intro: CAS:66722-44-9
Purity:0.99 Package:25KG;5KG;1KG;500G

Lastest Price from Bisoprolol manufacturers

  • Bisoprolol
  • US $2.00 / kg
  • 2019-07-06
  • CAS:66722-44-9
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Bisoprolol Basic information
Cardiovascular drugs Uses Category Toxicity grading Acute toxicity Flammability hazard characteristics Storage Characteristics Extinguishing agent
Product Name:Bisoprolol
Synonyms:1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol;(R)-1-(Isopropylamino)-3-[4-(2-isopropoxyethoxymethyl)phenoxy]-2-propanol;(R)-1-[(1-Methylethyl)amino]-3-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-2-propanol;1-[isopropylamino]-3-[isopropoxyethoxymethylphenoxy]-2-propanol;1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol;Bisoprolol-d5 HeMifuMarate;1-(4-((2-isopropoxyethoxy)Methyl)phenoxy)-3-(isopropylaMino)propan-2-ol;1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-( isopropylamino)-2-propanol fumaric acid salt
CAS:66722-44-9
MF:C18H31NO4
MW:325.44
EINECS:613-980-5
Product Categories:Isotope Labelled Compounds;API;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Pharmaceuticals
Mol File:66722-44-9.mol
Bisoprolol Structure
Bisoprolol Chemical Properties
Melting point 100 °C
Boiling point 445.0±45.0 °C(Predicted)
density 1.033±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer, Under Inert Atmosphere
form neat
pkapKa 9.57(H2O(extrap) t=25±1 Iunde?ned Aratmosphere) (Uncertain)
Water Solubility 5.5ug/L(100 ºC)
CAS DataBase Reference66722-44-9(CAS DataBase Reference)
NIST Chemistry ReferenceBisoprolol(66722-44-9)
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 1
RTECS UB8380000
HazardClass IRRITANT
MSDS Information
Bisoprolol Usage And Synthesis
Cardiovascular drugsBisoprolol is successfully developed by the German Merck in 1978, in the world ,it is already the drug of choice on clinicalcommonly used to treat hypertension, angina, arrhythmias and heart failure and other cardiovascular diseases, the product is highly selective β1-adrenergic receptor blocker,it has hydrophilic and lipophilic properties,it has no intrinsic sympathomimetic activity and membrane stability, and its negative inotropic effect is weaker.It has two β receptor binding sites with ultra-high affinity and high affinity ,its drug action is extremely powerful,it is 7 to 10 times stronger than atenolol and metoprolol . It has highly β1 receptor selectivity, selective research about model complex β1/β2 finds out that: propranolol is 1/3,atenolol is 20/1 , bisoprolol is 60/1. Another study compares the β1/β2 selectivity of metoprolol and bisoprolol, the results show that the former is 74/1,the latter is 119/1. Like other β-blockers, bisoprolol by blocking heartβ1 receptors, and inhibiting the renin-angiotensin system, plays a role in the treatment of hypertension, angina, arrhythmia. Recent studies indicate that substance P has effect on dilating the blood vessels to reduce the role of peripheral resistance, content of substance P in patients with hypertension decreases significantly,there is a significant rebound of substance P while there is a decrease in blood pressure after the treatment of bisoprolol, which may be one of the possible mechanisms of antihypertension . Another study shows that bisoprolol can not only decrease the blood pressure, but can also improve diastolic function; it has no adverse effects on blood sugar, blood lipids , conclusion in diabetics is also like this . It is mainly used to treat supraventricular tachycardia, atrial fibrillation, ventricular premature contraction, coronary heart disease, angina, mild to moderate hypertension, it is also used in heart failure caused by dilated cardiomyopathy and ischemic heart disease.
Oral F is up to 88%. Tmax is 1.5~3 h. PPB is 30%. Plasma clearance T1/2 is 10~12 h. The one dose effect can be maintained for 24 h. Because its hydrophilic character is equal to lipophilic character, its adverse reactions on central nervous system are lighter than metoprolol with lipophilic character,and its adverse reactions on renal function is smaller compared withatenolol with hydrophilic character . Bisoprolol have two equal clearance ways ,half of it is metabolized to the non-active substances in the liver , the other half is excreted in the form of the prototype by the kidneys. [Note and taboos]it is similar to atenolol.
The above information is edited by the chemicalbook of Tian Ye.
UsesIt is used for the treatment of cardiovascular and cerebrovascular diseases.
CategoryToxic Substances
Toxicity gradingMiddle toxic
Acute toxicityIntravenous-Mouse LD50: 164 mg/kg.
Flammability hazard characteristicsCombustible; combustion produces toxic nitrogen oxide gases.
Storage CharacteristicsVentilated, low-temperature ,dry storeroom.
Extinguishing agentWater, dry powder, foam, sand.
Chemical PropertiesYellow Oil
UsesA selective a-adrenergic blocker. Used as an antihypertensive
UsesA selective β-adrenergic blocker. Used as an antihypertensive.
Enzyme inhibitorThis oral cardiospecific β-blocker (FWfree-base = 325.45 g/mol; CAS 66722- 44-9; IUPAC: (RS)-1-{4-[(2-isopropoxyethoxy)methyl]phenoxy}-3- (isopropylamino)propan-2-ol), also named Zebeta? (oral tablets as fumarate salt), selectively targets β1-adrenergic receptors, blocking epinephrine stimulation of β1-adrenoreceptors that are concentrated in the heart muscle cells and heart conduction tissue as well as kidney juxtaglomerular cells. Bisoprolol is used to treat hypertension, coronary heart disease, arrhythmias, ischemic heart diseases, and myocardial infarction after the acute event. Given such versatility, bisoprolol is understandably included in the World Health Organization's List of Essential Medicines. Pharmacokinetics: Bioavailability > 90%; Hepatic metabolism (50%) by CYP2D6 and CYP3A4; Biological t1/2 = 10-12 hours.
Bisoprolol Preparation Products And Raw materials
Tag:Bisoprolol(66722-44-9) Related Product Information
BISOPROLOL FUMARATE BISOPROLOL HEMIFUMARATEIMP. B (PHARMEUROPA): (RS)-1-ISOPROPYLAMINO-3-[4-(2-PROPOXYETHOXYMETHYL)PHENOXY]PROPAN-2-OL BISOPROLOL HEMIFUMARATE IMP. J (PHARMEUROPA): (2RS)-3-[4-((2-ISOPROPOXY-ETHOXY)METHYL)PHENOXY]-1,2-PROPANEDIOL BISOPROLOL FUMERATE BISOPROLOL FUMARATE MM(CRM STANDARD) BISOPROLOL HEMIFUMARATE SALT BISOPROLOL HEMIFUMARATE IMP. Q (PHARMEUROPA): (2RS)-1-ISOPROPYL-AMINO-3-[4-(2-METHOXYETHOXY)METHYL]-PHENOXY-2-PROPANOL BISOPROLOL HEMIFUMARATE IMP. M (PHARMEUROPA): 4-[(2-ISOPROPOXY-ETHOXY)METHYL]PHENOL S-(-)-BISOPROLOL R-(+)-BISOPROLOL TIMTEC-BB SBB005914 Bisoprolol Phenetidine 2-Ethoxyphenol BISOPROLOL HEMIFUMARATE,(+/-)-BISOPROLOL HEMIFUMARATE DIETHOXYMETHANE Ethoxyquin acetic acid, triethoxy-, ethyl ester