- 4-Aminophthalic acid
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- $167.44 / 25Kg/Drum
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2025-11-06
- CAS:5434-21-9
- Min. Order: 25Kg/Drum
- Purity: 98.50%HPLC
- Supply Ability: 6tons/month
- 4-Aminophthalic acid
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- $10.00 / 1KG
-
2025-11-06
- CAS:5434-21-9
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 10 mt
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| | 4-Aminophthalic acid Basic information |
| | 4-Aminophthalic acid Chemical Properties |
| Melting point | 344 °C (dec.)(lit.) | | Boiling point | 465.1±40.0 °C(Predicted) | | density | 1.551±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | pka | 3.41±0.10(Predicted) | | form | powder to crystal | | color | White to Gray to Brown | | BRN | 2723405 | | InChI | InChI=1S/C8H7NO4/c9-4-1-2-5(7(10)11)6(3-4)8(12)13/h1-3H,9H2,(H,10,11)(H,12,13) | | InChIKey | OXSANYRLJHSQEP-UHFFFAOYSA-N | | SMILES | C1(C(O)=O)=CC=C(N)C=C1C(O)=O | | CAS DataBase Reference | 5434-21-9(CAS DataBase Reference) | | EPA Substance Registry System | 4-Aminophthalic acid (5434-21-9) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29224999 |
| | 4-Aminophthalic acid Usage And Synthesis |
| Chemical Properties | Beige powder | | Uses | peptide synthesis | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | The general procedure for the synthesis of 4-amino phthalic acid from 4-nitrophthalic acid was as follows: 1 g (4.73 mmol) of 4-nitrophthalic acid was dissolved in 10 ml of anhydrous ethanol. The solution was stirred and degassed at room temperature and under argon protection. Subsequently, 50 mg of 5% palladium/carbon catalyst was added at once and hydrogen was passed into the solution for hydrogenation reaction. After 3 hours of reaction, the reaction mixture was filtered through diatomaceous earth to remove the catalyst. The filtrate was concentrated by evaporation to give an orange oily product with a mass of 820 mg and a yield of 96%. The structure of the product was confirmed by 1H NMR (DMSO-d6) with the following chemical shifts: 3.32 (1H, s), 5.95 (1H, s), 6.49-6.53 (2H, m), 7.46-7.50 (1H, d, J = 8.8 Hz), 12.33 (2H, COOH, s). | | References | [1] Patent: US6689922, 2004, B1. Location in patent: Page column 20
[2] Patent: US6706725, 2004, B1. Location in patent: Page column 11
[3] Chemical Communications, 2017, vol. 53, # 62, p. 8751 - 8754
[4] Justus Liebigs Annalen der Chemie, 1881, vol. 208, p. 230
[5] Journal of the American Chemical Society, 1908, vol. 30, p. 1143 |
| | 4-Aminophthalic acid Preparation Products And Raw materials |
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