- 3-Nitrophthalic acid
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- $12.56 / 25Kg/Drum
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2024-04-26
- CAS:603-11-2
- Min. Order: 25Kg/Drum
- Purity: 99.5%HPLC
- Supply Ability: 20tons/month
- 3-nitrophthalic acid
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- $0.00 / 1Kg
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2024-03-29
- CAS:603-11-2
- Min. Order: 1Kg
- Purity: 99.9%
- Supply Ability: 200tons
- 3-Nitrophthalic acid
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- $100.00 / 1KG
-
2023-12-26
- CAS:603-11-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: g-kg-tons, free sample is available
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| | 3-Nitrophthalic acid Basic information |
| | 3-Nitrophthalic acid Chemical Properties |
| Melting point | 210 °C (dec.) (lit.) | | Boiling point | 350.79°C (rough estimate) | | density | 1.6342 (rough estimate) | | vapor density | 7.3 (vs air) | | refractive index | 1.5282 (estimate) | | storage temp. | Store below +30°C. | | solubility | water: soluble5%, clear to slightly hazy, colorless to faint yellow or tan | | form | Powder | | pka | pK1:1.88 (25°C) | | color | Off-white to light yellow | | Water Solubility | 20 g/L (25 ºC) | | Decomposition | 216 °C | | BRN | 2054269 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | KFIRODWJCYBBHY-UHFFFAOYSA-N | | CAS DataBase Reference | 603-11-2(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Nitrophthalic acid(603-11-2) | | EPA Substance Registry System | 3-Nitrophthalic acid (603-11-2) |
| | 3-Nitrophthalic acid Usage And Synthesis |
| Chemical Properties | Pale yellow crystals. soluble in hot water, methanol, ethanol, slightly soluble in ether, insoluble in chloroform, carbon tetrachloride, carbon disulfide, benzene. | | Uses | 3-Nitrophthalic Acid is a useful chemical in organic synthesis. It is also an impurity of Apremilast. | | Uses | 3-Nitrophthalic acid may be used as starting reagent in the synthesis of modified 2-iodoxybenzoic acid derivatives. It may be used in the synthesis of brucinium 2-carboxy-6-nitrophthalate dihydrate (systematic name: 2,3-dimethoxy-10-oxostrychnidinium 2-carboxy-6-nitrophthalate dihydrate), via heating with brucine. | | Preparation | Phthalic anhydride was added to concentrated sulfuric acid, stirring under the passage of water vapor heating to 80 °C, fuming nitric acid was added dropwise, the reaction temperature to maintain 100-110°C, add the end of the heat above 110°C for 2h, placed in the overnight pour into the water, and filtered. The filter cake was recrystallized with water to obtain 3-Nitrophthalic acid. Yield of about 30%. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 39, p. 2468, 1974 DOI: 10.1021/jo00930a051 | | General Description | 3-Nitrophthalic acid is a degradation product of isoxaben herbicide. It acts as ligand and forms rare-earth complexes. | | Safety Profile | A preparative hazard. When heated to decomposition it emits toxic fumes of NOx. | | Purification Methods | Crystallise 3-nitrophthalic acid from hot water (1.5mL/g). Dry it in air. The amide has m 201o (from EtOH). [Beilstein 9 H 823, 9 IV 3275.] |
| | 3-Nitrophthalic acid Preparation Products And Raw materials |
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