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| | N-(Trimethylsilyl)imidazole Basic information |
| | N-(Trimethylsilyl)imidazole Chemical Properties |
| Melting point | -42 °C | | Boiling point | 93-94 °C14 mm Hg(lit.) | | density | 0.957 g/mL at 20 °C | | refractive index | n20/D 1.475(lit.) | | Fp | 42 °F | | storage temp. | Store below +30°C. | | solubility | Chloroform | | form | Liquid | | pka | 7.96±0.10(Predicted) | | Specific Gravity | 0.956 | | color | Clear colorless to yellow | | Water Solubility | decomposes | | Sensitive | Moisture Sensitive | | Hydrolytic Sensitivity | 7: reacts slowly with moisture/water | | BRN | 606148 | | Stability: | Air and Moisture Sensitive | | InChIKey | YKFRUJSEPGHZFJ-UHFFFAOYSA-N | | CAS DataBase Reference | 18156-74-6(CAS DataBase Reference) | | NIST Chemistry Reference | 1h-Imidazole, 1-(trimethylsilyl)-(18156-74-6) | | EPA Substance Registry System | 1H-Imidazole, 1-(trimethylsilyl)- (18156-74-6) |
| | N-(Trimethylsilyl)imidazole Usage And Synthesis |
| Chemical Properties | Colorless transparent liquid | | Physical properties | bp 93–94 °C/14 mmHg; fp 5 °C; d 0.956 g cm?3. | | Uses | N-(Trimethylsilyl)imidazole is a silylating agent for alcohols and 1,3-dicarbonyl compounds; reaction with esters to give imidazolides; preparation of
O-trimethylsilyl monothioacetals; aromatization of the A-ring of steroids. It participates in the reactions of Hydroxyl Silylation Reactions, Silyl Aminal Formation Reactions, Nitrogen Silylation Reactions, Acyl Imidazole Formation, Michael Addition Reactions, Substitution Reactions, Phosphoroimidazolidate Formation, and other uses. | | Uses | N-(trimethylsilyl) imidazole (TMSim) is quite reactive with hydroxyl groups in a variety of analytes including a variety of lipids.As with other derivatization reactions,microwave heating can greatly improve process efficiency. | | Uses | Silylating reagent for the protection of hydroxyl groups in the presence of amine functionalities.1 | | Uses | A general silylating agent, particularly for alcohols. An intermediate for the synthesis of imidazole derivatives. | | Definition | ChEBI: A member of the class of imidazoles in which the hydrogen at position 1 is replaced by a trimethylsilyl group. N-trimethylsilylimidazole is a derivatisation agent used in gas chromatography/mass spectrometry applications. | | General Description | 1-(Trimethylsilyl)imidazole (TMSIM) has high silyl donor ability. It does not react with amino groups and also does not help in formation of enol-ether on unprotected ketone groups. It is useful as a silylating agent for ecdysones, norepinephrine, dopamine, steroids, sugars, sugar phosphates and ketose isomers. | | reaction suitability | reagent type: derivatization reagent
reaction type: Silylations |
| | N-(Trimethylsilyl)imidazole Preparation Products And Raw materials |
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