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Fosfomycin tromethamine

Fosfomycin tromethamine Suppliers list
Company Name: Shanghai Yingrui Biopharma Co., Ltd.
Tel: +86-21-33585366 E-mail:sales03@shyrchem.com
Email: sales03@shyrchem.com
Products Intro: Product Name:Fosfomycin tromethamine
CAS:78964-85-9
Purity:99% Package:100g;500g;1kg;25kg...
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Fosfomycin tromethamine
CAS:78964-85-9
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:78964-85-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: 0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
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Products Intro: Product Name:Fosfomycin Tromethaminel
CAS:78964-85-9
Purity:As coa Package:As request Remarks:78964-85-9
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: 86-0551-65418684 18949823763
Email: info@tnjchem.com
Products Intro: Product Name:Fosfomycin tromethamine
CAS:78964-85-9
Purity:99.9% Package:1KG;5USD

Lastest Price from Fosfomycin tromethamine manufacturers

  • Fosfomycin tromethamine
  • US $7.00 / ASSAYS
  • 2019-07-06
  • CAS:78964-85-9
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1000KG

Related articles

Fosfomycin tromethamine Basic information
Product Name:Fosfomycin tromethamine
Synonyms:(3-methyloxiranyl)-phosphonicaci(2r-cis)-phosphonicacicompd.with2-amino-2-(hydroxy;fosfomycincompd.withtrometamol;fosfomycintrometamolsalt;methyl)-1,3-propanediol(1:1);Tromethamine fosfosmycin;Fosfomycin Tromethamine (800 mg);FosfoMycin troMethaMine API;Fosfomycin trometamolUSP, 98.0%-102.0%
CAS:78964-85-9
MF:C7H18NO7P
MW:259.19
EINECS:279-018-8
Product Categories:API;Antibiotics
Mol File:78964-85-9.mol
Fosfomycin tromethamine Structure
Fosfomycin tromethamine Chemical Properties
solubility Very soluble in water, slightly soluble in ethanol (96 per cent) and in methanol, practically insoluble in acetone.
InChIKeyQZJIMDIBFFHQDW-LMLSDSMGSA-N
Safety Information
HS Code 2941906000
MSDS Information
Fosfomycin tromethamine Usage And Synthesis
Chemical PropertiesWhite to off-white powder
UsesPhosphonic acid derivative; antibacterial.
Brand nameMonurol (Zambon).
General DescriptionFosfomycin tromethamine (Monurol) is a phosphonic acidepoxide derivative that was initially isolated from fermentationsof Streptomyces spp. Making the tromethamine salt greatly expanded the therapeutic utility of this antibacterial because water solubilityincreased enough to allow oral administration.
Fosfomycin is a broad-spectrum, bactericidal antibacterialthat inhibits the growth of E. coli, S. aureus, andSerratia, Klebsiella, Citrobacter, Enterococcus, andEnterobacter spp. at a concentration less than 64 mg/L.Currently fosfomycin is recommended as single-dose therapyfor uncomplicated urinary tract infections. It possessesin vitro efficacy similar to that of norfloxacin and trimethoprim-sulfamethoxazole.
Fosfomycin covalently inactivates the first enzyme in thebacterial cell wall biosynthesis pathway, UDP-N-acetylglucosamineenolpyruvyl transferase (MurA) by alkylation ofthe cysteine-115 residue. The inactivation reaction occursthrough nucleophilic opening of the epoxide ring. Resistanceto fosfomycin can occur through chromosomal mutationsthat result in reduced uptake or reduced MurA affinity for theinhibitor. Plasmid-mediated resistance mechanisms involveconjugative bioinactivation of the antibiotic with glutathione.The frequency of resistant mutants in in vitro studies hasbeen low, and there appears to be little cross-resistance betweenfosfomycin and other antibacterials.
Fosfomycin tromethamine Preparation Products And Raw materials
Tag:Fosfomycin tromethamine(78964-85-9) Related Product Information
Meglumine Antipyrine Amino tris(methylene phosphonic acid) PROPANE-1-PHOSPHONIC ACID TRISTEARIN Disodium pamidronate 1-Hydroxyethylidene-1,1-diphosphonic acid Fosfomycin tromethamine Glycine Amino alcohol Tris Base Lithium diisopropylamide Disodium phosphonomycin 2-[(4-AMINO-PHENYL)-ETHYL-AMINO]-ETHANOL CLODRONIC ACID 1,2,4-Butanetriol Zoledronic acid Fosfomycin