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(TRIMETHYLSILYL)DIAZOMETHANE

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Products Intro: Product Name:(TRIMETHYLSILYL)DIAZOMETHANE
CAS:18107-18-1
Purity:99% Package:5KG;1KG Remarks:MG25332
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Products Intro: Product Name:(TRIMETHYLSILYL)DIAZOMETHANE
CAS:18107-18-1
Purity:0.99 Package:25kg;5KG;1KG
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Products Intro: Product Name:(TRIMETHYLSILYL)DIAZOMETHANE
CAS:18107-18-1
Purity:99% Package:1KG,5KG,10KG
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Products Intro: Product Name:CAS18107-18-1 diazomethyl(trimethyl)silane
CAS:18107-18-1
Purity:99% Package:25KG;5KG;1KG
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Products Intro: CAS:18107-18-1
Package:g-Kg Remarks:Light yellow liquid

(TRIMETHYLSILYL)DIAZOMETHANE manufacturers

(TRIMETHYLSILYL)DIAZOMETHANE Basic information
Product Name:(TRIMETHYLSILYL)DIAZOMETHANE
Synonyms:(TRIMETHYLSILYL)DIAZOMETHANE;(Trimethylsilyl)diazomethane, ca. 2.0M solution in hexanes, tech.;Trimethylsilyldiazomethane,10%inhexane;TRIMETHYLSILYLDIAZOMETHANE, 1.0M IN METHYLENE CHLORIDE;(Trimethylsilyl)diazomethane solution 2M;(TRIMETHYLSILYL)DIAZOMETHANE, 2.0 M IN &;(Trimethylsilyl)diazomethane, 2M in hexanes;Trimethylsilyldiazomethane (ca. 10% in Hexane, ca. 0.60mol/L)
CAS:18107-18-1
MF:C4H10N2Si
MW:114.22
EINECS:
Product Categories:Analytical Chemistry;Diazomethane Precursors & Equivalents (GC Derivatizing Reagents);Esterification & Alkylation (GC Derivatizing Reagents);GC Derivatizing Reagents;Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry
Mol File:18107-18-1.mol
(TRIMETHYLSILYL)DIAZOMETHANE Structure
(TRIMETHYLSILYL)DIAZOMETHANE Chemical Properties
Boiling point 96 °C
density 0.773 g/mL at 25 °C
refractive index 1.4362
Fp −31 °F
storage temp. Refrigerator
solubility Sol most organic solvents; insol H2O.
form Solution
color White
Water Solubility Immiscible with water. Miscible with organic solvents.
Sensitive Moisture & Light Sensitive
BRN 1902903
Stability:Shock Sensitive
InChIInChI=1S/C4H10N2Si/c1-7(2,3)4-6-5/h4H,1-3H3
InChIKeyONDSBJMLAHVLMI-UHFFFAOYSA-N
SMILESC(=[N+]=[N-])[Si](C)(C)C
CAS DataBase Reference18107-18-1(CAS DataBase Reference)
EPA Substance Registry SystemSilane, (diazomethyl)trimethyl- (18107-18-1)
Safety Information
Hazard Codes F+,Xn,N,F,T,T+
Risk Statements 12-19-22-66-67-65-62-51/53-48/20-38-11-23-39/26-26-45
Safety Statements 9-16-29-33-36/37-61-62-45-28-53
RIDADR UN 1208 3/PG 2
WGK Germany 3
10
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29270000
Hazardous Substances Data18107-18-1(Hazardous Substances Data)
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
(TRIMETHYLSILYL)DIAZOMETHANE Usage And Synthesis
Chemical Propertiesclear yellow solution
Physical propertiesbp 96 °C/775 mmHg; nD/25 1.4362.2
UsesTrimethylsilyldiazomethane is used as one-carbon homologation reagent; stable, safe substitute for diazomethane;participating in the synthesis reactions of insertion reactions;ketenylation reactions;preparation of homoallylic sulfides;pericyclic reactions;[C-N-N] 1,3-dipole for the preparation of azoles.
UsesReactant for preparation of: &bull Macrolactam analogs of the natural product macrolide (-)-A26771B with improved metabolic stability and antibacterial activity &bull Aigialomycin D analogues as protein kinase inhibitors for cancer treatment &bull Unnatural α-amino acid derivatives containing gem-bisphosphonates via Michael addition reaction &bull Capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates &bull Stictamides A-C as matrix metallopeptidase 12 (MMP12) inhibitors with antitumor invasion activity &bull Endothelin converting enzyme (ECE) Inhibitors WS 75624A and WS 75624B via a cross-metathesis approach &bull Ent-kaurene derivatives as anti-inflammatory agents &bull Desmosdumotin C analogs as potent antitumor agents acting via activation of spindle assembly checkpoint &bull Imidazolo[2,1-b]benzothiazole derivatives as potential p53 inhibitors
Uses(Trimethylsilyl)diazomethane is used as an analyte in the determination of some phenolic organohalogens in human serum by GC-MS.
PreparationTrimethylsilyldiazomethane is prepared by the diazo-transfer reaction of trimethylsilylmethylmagnesium chloride with diphenyl phosphorazidate (DPPA) (eq 1).

18107-18-1 synthesis

General Description(Trimethylsilyl)diazomethane is considered as a non-explosive substitute to diazomethane for the homologation of carbonyl derivatives, mainly ketones, via reactions such as Tiffeneau-Demjanov rearrangement.
Tag:(TRIMETHYLSILYL)DIAZOMETHANE(18107-18-1) Related Product Information
2-METHOXYPHENYLMAGNESIUM BROMIDE DIMETHYLALUMINUM CHLORIDE Chloromethane 4-ETHYLPHENYLMAGNESIUM BROMIDE 4-THIOANISOLEMAGNESIUM BROMIDE Tricyclohexyl phosphine 3-(DIMETHYLAMINO)PROPYL CHLORIDE HYDROCHLORIDE (TRIMETHYLSILYL)METHYLLITHIUM P-TOLYLMAGNESIUM CHLORIDE 4-Methoxyphenylmagnesium bromide HEXANES Hexane TRIMETHYLSILANE Diazomethane (TRIMETHYLSILYL)DIAZOMETHANE

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