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Propionitrile

Propionitrile Basic information
Product Name:Propionitrile
Synonyms:C2H5CN;cyanured’ethyle;ethanecarbonitrile;Ether cyanatus;ethercyanatus;Propionitrile,ethylcyanide;propionitrile0;Propionitrile-ethyl cyanide
CAS:107-12-0
MF:C3H5N
MW:55.08
EINECS:203-464-4
Product Categories:Organics;Building Blocks;C1 to C5;Chemical Synthesis;Cyanides/Nitriles;Nitrogen Compounds;Organic Building Blocks
Mol File:107-12-0.mol
Propionitrile Structure
Propionitrile Chemical Properties
Melting point -93 °C
Boiling point 97 °C(lit.)
density 0.772 g/mL at 25 °C(lit.)
refractive index n20/D 1.366(lit.)
Fp 43 °F
storage temp. Flammables area
Water Solubility decomposes. 5-10 g/100 mL at 23 ºC
FreezingPoint -93℃
Merck 14,7827
BRN 773680
Stability:Stable. Flammable. Note low flash point. Incompatible with strong oxidising agents, strong bases, strong acids, strong reducing agents.
CAS DataBase Reference107-12-0(CAS DataBase Reference)
NIST Chemistry ReferencePropanenitrile(107-12-0)
EPA Substance Registry SystemPropanenitrile(107-12-0)
Safety Information
Hazard Codes F,T+,T
Risk Statements 11-20-25-27-36-23/24/25
Safety Statements 9-16-28-36/37-45-27
RIDADR UN 2404 3/PG 2
WGK Germany 1
RTECS UF9625000
TSCA Yes
HazardClass 3
PackingGroup II
Hazardous Substances Data107-12-0(Hazardous Substances Data)
ToxicityLD50 orally in rats: 39 mg/kg (Smyth)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Propionitrile Usage And Synthesis
Chemical PropertiesClear liquid
Chemical PropertiesPropionitrile is a colorless liquid with a pleasant, sweetish, ethereal odor.
UsesPropionitrile is an intermediate for organic syntheses, e.g. Houben-Hoesch reaction, as well as for pharmaceuticals, e.g. ketoprofen and fragrances. Product Data Sheet
DefinitionChEBI: A nitrile that is acrylonitrile in which the carbon-carbon double bond has been reduced to a single bond.
General DescriptionA colorless liquid with an ether-like odor. Density 0.683 g / cm3. Flash point 61°F. Toxic by inhalation, skin absorption, and ingestion. Vapors are heavier than air. Used as a solvent, and to make other chemicals.
Air & Water ReactionsHighly flammable. Soluble in water.
Reactivity ProfilePropionitrile is incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents. After refluxing for 24 hours at 221°F, a mixture of Propionitrile with N-bromosuccinimide exploded.
HazardToxic by ingestion and inhalation. Flammable, dangerous fire risk.
Health HazardPropionitrile is highly toxic. This super toxic compound has a probable oral lethal dose in humans of less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lb.) person. It is a mild to moderate skin and eye irritant.
Fire HazardWhen heated to decomposition, Propionitrile emits toxic fumes of nitrogen oxides and cyanide. Propionitrile is a flammable/combustible material and may be ignited by heat, sparks or flames. Vapors may travel to a source of ignition and flash back. Container may explode in heat of fire. Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Generates cyanide ions. Poisonous on contact with acids. stable, but may become unstable at elevated temperatures and pressures.
Safety ProfilePoison by ingestion, skin contact, intravenous, and intraperitoneal routes. Moderately toxic by inhalation. Experimental teratogenic effects. Other experimental reproductive effects. A skin and eye irritant. Dangerous fire hazard when exposed to heat, flame (sparks), oxidners. Mixture with N- bromosuccinimide may explode when heated. To fight fire, use water spray, foam, mist, CO2, dry chemical. When heated to decomposition it emits toxic fumes of NOx and CN-. Used as a solvent in petroleum refining, and as a raw material for drug manufacture. See also NITRILES.
Potential ExposureUsed as a solvent in petroleum refin- ing, as a chemical intermediate; a raw material for drug manufacture; and a setting agent.
First aidIf this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ- ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi- cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
ShippingUN2404 Propionitrile, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous material. UN1992 Flammable liquids, toxic, n.o.s., Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous materials, Technical Name Required.
Purification MethodsShake the nitrile with dilute HCl (20%), or with conc HCl until the odour of isonitrile has gone, then wash it with water, and aqueous K2CO3. After a preliminary drying with silica gel or Linde type 4A molecular sieves, it is stirred with CaH2 until hydrogen evolution ceases, then decant and distil from P2O5 (not more than 5g/L, to minimise gel formation). Finally, it is refluxed with, and slowly distilled from CaH2 (5g/L), taking precautions to exclude moisture. [Beilstein 2 IV 728.]
IncompatibilitiesIncompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlo- rine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides., reducing agents. Hydrogen cyanide is produced when propionitrile is heated to decomposition. Reacts with acids, steam, warm water; producing toxic and flammable hydrogen cyanide fumes. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompati- ble with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .
Waste DisposalAlcoholic NaOH followed by calcium hypochlorite may be used, as may incineration . Consult with environmental regulatory agencies for guid- ance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
Tag:Propionitrile(107-12-0) Related Product Information
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