Is oxalyl chloride toxic?
Nov 6,2024
Oxalyl chloride with the formula (COCl)2, is one of the most versatile applicable organic reagents in chemical transformations. It is a colorless and sharp smelling liquid belonging to the family of diacetyl chloride. Oxalyl chloride can be produced by treating oxalic acid with PCl5.

Oxalyl chloride is sensitive to moisture. It is employed in various chemical transformations such as chlorination, oxidation, reduction, dehydration, decarboxylation, and formylation reactions as well as ring cleavage of epoxides.
Oxalyl chloride is a highly toxic chemical compound that can cause severe health problems if improperly handled. Its toxicity is mainly due to its ability to produce hydrochloric acid, carbon monoxide, and oxalic acid when it reacts with water or moisture in the air. These compounds can cause severe damage to the respiratory system, eyes, skin, and other organs if inhaled, ingested, or exposed to the skin. Due to its highly reactive nature and potential to cause severe health problems, proper safety measures must be taken when handling oxalyl chloride.
References:
[1] LEYLA MOHAMMADKHANI Prof M M H. Oxalyl Chloride: A Versatile Reagent in Organic Transformations[J]. ChemistrySelect, 2019, 4 20: 5995-6413. DOI:10.1002/slct.201900120.
- Related articles
- Related Qustion
- Reactions and Applications of Oxalyl Chloride Apr 19, 2024
Oxalyl chloride has found general application for the preparation of carboxylic acid chlorides since the reagent was introduced by Adams and Ulich.
- What is Oxalyl chloride? Sep 4, 2023
Chlorine oxalate is a highly toxic substance and a versatile reagent for organic transformation
- The Synthesis of Oxalyl Chloride Nov 23, 2022
The passage introduces the synthesis of Oxalyl chloride.
Supplementation with pyridoxal 5'-phosphate monohydrate can synthesize neurotransmitters such as dopamine and serotonin, maintaining a healthy nervous system.....
Nov 4,2025Biochemical EngineeringTrandolapril is a non-sulfhydryl ACE inhibitor. It is a prodrug rapidly hydrolyzed mainly in the liver to its biologically active metabolite, trandolaprilat.....
Nov 6,2024APIOxalyl chloride
79-37-8You may like
- A Review on the Structural Properti....
Nov 5, 2025
- The Lewis structure of Fluoroethane
Oct 29, 2025
- Pyroxasulfone: A highly efficient herbicide
Oct 29, 2025
- Oxalyl chloride
-
- $1.00 / 50KG
- 2025-11-19
- CAS:79-37-8
- Min. Order: 1000KG
- Purity: 99%
- Supply Ability: Q: 20000 MT
- Oxalyl chloride
-
- $1.00 / 1PCS
- 2025-11-14
- CAS:79-37-8
- Min. Order: 1PCS
- Purity: 99%
- Supply Ability: 100mt
- Oxalyl chloride
-
- $0.00 / 1kg
- 2025-06-20
- CAS:79-37-8
- Min. Order: 1kg
- Purity: 0.99
- Supply Ability: 20tons






