What is Folinic acid?

The main component of leucovorin(Folinic acid） is calcium leucovorin. Calcium folinate, chemical name N-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydro-6-pteridyl)methyl]amino] Benzoyl-L-glutamate calcium salt, white to slightly yellow crystal or amorphous powder; odorless. Dissolved in water, almost insoluble in ethanol or ether; dissolved in 0.1mol/L sodium hydroxide solution. It is a derivative of folic acid, which is a vitamin required for DNA synthesis, DNA repair and DNA methylation, and it also acts as a cofactor in biological reactions involving folic acid.

Indications

Folinic acid is suitable for:

1. It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.).

2. It is used to prevent severe toxic effects caused by methotrexate overdose or high-dose treatment.

3. Megaloblastic anemia caused by folic acid deficiency.

4. When combined with fluorouracil, it is used to treat advanced colon cancer and rectal cancer.