PP121
中文名称 | PP121 |
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中文同义词 | PP121 1-环戊基-3-(1H-吡咯并[2,3-B]吡啶-5-基)-1H-吡唑并[3,4-D]嘧啶-4-胺;1-环戊基-3-(1H-吡咯并[2,3-B]吡啶-5-基)-1H-吡唑并[3,4-D]嘧啶-4-胺;多靶点激酶抑制剂(PP121);化合物PP121;PP121,酪氨酸和磷酸肌醇激酶的双重抑制剂 |
英文名称 | 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
英文同义词 | 1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;PP 121;4-(Pyridin-3-yl) pyriMidin-2-aMine IMatinib;1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine PP 121;PP121;PP-121;PTK/PI 3-K/mTOR Inhibitor, PP121;1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amine;CS-431 |
CAS号 | 1092788-83-4 |
分子式 | C17H17N7 |
分子量 | 319.36 |
EINECS号 | |
相关类别 | 蛋白酪氨酸激酶;小分子抑制剂,天然产物;小分子抑制剂;细胞生物学试剂;标准品;Inhibitors |
Mol文件 | 1092788-83-4.mol |
结构式 |
PP121 性质
密度 | 1.63 |
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储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:>10mg/mL |
形态 | 白色固体 |
酸度系数(pKa) | 12.79±0.40(Predicted) |
颜色 | 米白色 |
VEGFR2 12 nM (IC 50 ) |
PDGFR 2 nM (IC 50 ) |
mTOR 10 nM (IC 50 ) |
DNK-PK 60 nM (IC 50 ) |
Src 14 nM (IC 50 ) |
Oral administration of PP121 remarkably inhibits Eca-109 xenograft growth. Mice body weights are not significantly affected by PP121 or the vehicle treatment. PP121 oral administration dramatically inhibits activations of Akt-mTOR and NFkB in xenograft tumors. p-Akt Ser 473 and p-IKKa/b are both inhibited by PP121 administration.
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-10372 | PP121 | 5 mg | 523元 | |
2024/08/19 | HY-10372 | PP121 PP121 | 1092788-83-4 | 10mg | 837元 |