REVERSINE
中文名称 | REVERSINE |
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中文同义词 | 逆转素;逆转素, >96%;AURORA激酶抑制剂(REVERSINE);N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺;逆转素(ADENOSINE RECEPTOR拮抗剂) |
英文名称 | REVERSINE |
英文同义词 | 9H-Purine-2,6-diamine,N6-cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-;N6-Cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine;2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE;N6-CYCLOHEXYL-N2-(4-MORPHOLINOPHENYL)-9H-PURINE-2,6-DIAMINE;Picropodophyllin (PPP);N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine Reversine;Reversine N6-Cyclohexyl-N2-[4-(4-morpholinyl)phenyl]-1H-purine-2,6-diamine;REVERSINE |
CAS号 | 656820-32-5 |
分子式 | C21H27N7O |
分子量 | 393.49 |
EINECS号 | |
相关类别 | 小分子抑制剂;小分子抑制剂,天然产物;细胞生物学试剂;试剂盒-细胞分析试剂盒;Inhibitors |
Mol文件 | 656820-32-5.mol |
结构式 |
REVERSINE 性质
熔点 | 305℃ (decomposition) |
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沸点 | 736.4±70.0 °C(Predicted) |
密度 | 1.343±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:可溶7 mg/mL |
形态 | 固体 |
酸度系数(pKa) | 10.51±0.10(Predicted) |
颜色 | 米白色 |
稳定性 | 从购买之日起 2 年内保持稳定。 DMSO 溶液可在 -20°C 下保存长达 3 个月 |
Reversine是一种强效human A3 adenosine receptor拮抗剂,Ki为0.66 μM,也是一种泛aurora A/B/C kinase抑制剂,IC50分别为12 nM/13 nM/20 nM。也用于干细胞分化。Reversine induces myogenic lineage-committed cells to become multipotent mesenchymal progenitor cells, which proliferates and redifferentiates into bone and fat cells. Reversine, as an A3 adenosine receptor antagonist, competitively inhibits forskolin-stimulated cAMP production in stably transfected Chinese hamster ovary (CHO) cells. Reversine inhibits the phosphorylation of a well-known Aurora target, histone H3 in HCT116 cells. Moreover, Reversine potently blocks proliferation of multiple tumor cell types, and induces cell death. In primary human tumor samples, Reversine also inhibits colony formation of leukemic cells. When treated in combination, reversine and aspirin synergistically inhibit growth of cervical cancer cells and induce cell apoptosis.In mice inoculated with U14 tumors, Reversine (10 mg/kg i.p.) and aspirin cause more reduced tumor weight and tumor volume when compared with the control agents.
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-14711 | Reversine | 1 mg | 295元 | |
2024/08/19 | HY-14711 | REVERSINE Reversine | 656820-32-5 | 5mg | 651元 |