ChemicalBook CAS DataBase List 1-(4-METHYLPHENYL)-1 H-PYRROLE

1-(4-METHYLPHENYL)-1 H-PYRROLE synthesis

13synthesis methods

Product Name:1-(4-METHYLPHENYL)-1 H-PYRROLE
CAS Number:827-60-1
Molecular formula:C11H11N
Molecular Weight:157.21

696-59-3 Synthesis

696-59-3
408 suppliers
$7.00/25g

106-49-0
410 suppliers
$5.00/5G

827-60-1
37 suppliers
$110.00/500mg

Yield:827-60-1 99%

Reaction Conditions:

with acetic acid in water;1,2-dichloro-ethane; for 24 h;Reflux;Clauson-Kaas Synthesis;

Steps:

5.1.2. General procedure A for the synthesis of compounds 12 and13a-i

General procedure: A mixture of the appropriate aniline (10 mmol) and 2,5-dimethoxytetrahydrofuran (1.32 g, 10 mmol) in a mixture of 1,2-dichloroethane (20 mL), acetic acid (0.7 mL) and water (10 mL)was heated under reflux for 24 h. After removal of the solvent, thecrude residue was dissolved in a mixture of water (15 mL) anddichloromethane (20 mL). The organic extract was washed with a10% sodium carbonate solution (10 mL) and brine (10 mL) and driedover Na2SO4 and the solvent removed in vacuo. The resulting residuewaspurified by silica gel column chromatography to afford thedesired product 12 or 13a-i.

References:

Romagnoli, Romeo;Oliva, Paola;Salvador, Maria Kimatrai;Manfredini, Stefano;Padroni, Chiara;Brancale, Andrea;Ferla, Salvatore;Hamel, Ernest;Ronca, Roberto;Maccarinelli, Federica;Rruga, Fatlum;Mariotto, Elena;Viola, Giampietro;Bortolozzi, Roberta [European Journal of Medicinal Chemistry,2021,vol. 214,art. no. 113229]

624-31-7 Synthesis