1,7,8-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene synthesis
- Product Name:1,7,8-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene
- CAS Number:274-80-6
- Molecular formula:C6H5N3
- Molecular Weight:119.12
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Yield: 83.3%
Reaction Conditions:
at 120 - 140; for 19 h;
Steps:
2.2 Preparation of [1,2,4]triazolo[4,3-a]pyridine
Dissolve 2-hydrazinopyridine (2.6g, 23.8mmol) in triethyl orthoformate (25mL),Heated to 140 , the reaction for 3 hours, down to 120 , the reaction for 16 hours,Spin the solvent to dry, column chromatography (dichloromethane: methanol: NH3.H2O = 50: 1: 0.5),Compound 2.5g was obtained, yield: 83.3%.
References:
Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.;Wang Tingzhong;Liu Bin CN111170995, 2020, A Location in patent:Paragraph 0155; 0160-0162
4930-98-7
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50-00-0
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274-80-6
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$45.00/100mg
4930-98-7
251 suppliers
$5.00/1g
274-80-6
78 suppliers
$45.00/100mg
109-09-1
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274-80-6
78 suppliers
$45.00/100mg