2-[(6-Chloro-4-pyriMidinyl)oxy]-α-(diMethoxyMethyl)benzeneacetic Acid Methyl Ester synthesis
- Product Name:2-[(6-Chloro-4-pyriMidinyl)oxy]-α-(diMethoxyMethyl)benzeneacetic Acid Methyl Ester
- CAS Number:143230-42-6
- Molecular formula:C16H17ClN2O5
- Molecular Weight:352.77
1193-21-1
571 suppliers
$14.00/5g
40800-90-6
47 suppliers
$155.00/100mg
124-41-4
717 suppliers
$12.00/25g
143230-42-6
7 suppliers
inquiry
Yield:143230-42-6 85%
Reaction Conditions:
Stage #1: 3-(α-methoxy)methylene benzofuran-2-(3H)-ketone;sodium methylatewith 2-methyl-1,4-divinylpiperazine in methanol;acetonitrile at 15 - 20; for 0.5 h;
Stage #2: 4,6-dichloropyrimidine in methanol;acetonitrile; for 1 h;Solvent;Temperature;
Steps:
4
A 500 ml three-necked flask was charged with 46.6 g of compound A (98%, 0.26 mol), 130 ml of acetonitrile, stirred at room temperature, and then put 0.4 g of 2-methyl-divinylpiperazine, , the mixture was stirred,cooled to 15 ° C and 53.8 g of sodium methoxide of methanol (28.87%, 0.287 mol) was added dropwise. The dropwise addition was controlled for half an hour. After the addition was completed, the mixture was incubated at 20 ° C for 1 hour. Then add 46.6 g of dichloropyrimidine(98.5%, 0.308mol) .After 1h it was acidified by adding 36% hydrochloric acid to pH = 4, washed twice with water and agitated, and the crude compound B was obtained by desolvation. The yield was 85%.
References:
CN104725321,2017,B Location in patent:Paragraph 0020; 0021; 0025; 0027
![Benzeneacetic acid, 2-[(6-chloro-4-pyrimidinyl)oxy]-α-(methoxymethylene)-, methyl ester](/CAS/20210305/GIF/383428-73-7.gif)
1193-21-1
571 suppliers
$14.00/5g
40800-90-6
47 suppliers
$155.00/100mg
143230-42-6
7 suppliers
inquiry
1193-21-1
571 suppliers
$14.00/5g
40800-90-6
47 suppliers
$155.00/100mg
143230-42-6
7 suppliers
inquiry
![Methyl (E)-2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3-methoxyacrylate](/CAS/GIF/131860-97-4.gif)
131860-97-4
129 suppliers
$9.00/1g
