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General description Harmful effects and symptoms of poisoning Protective measures Chemical properties Uses Production method
Hexamethylphosphoramide structure
Chemical Name:
HPT;HMPA;HMPTA;HEMPA;ent50882;ENT 50882;ent50,882;HMPT/HMPA;ENT 50,882;hexamethyl
Molecular Formula:
Formula Weight:
MOL File:

Hexamethylphosphoramide Properties

Melting point:
7 °C (lit.)
Boiling point:
230-232 °C/740 mmHg (lit.)
1.03 g/mL at 25 °C (lit.)
vapor density 
6.18 (vs air)
vapor pressure 
0.07 mm Hg ( 25 °C)
refractive index 
n20/D 1.459(lit.)
Flash point:
222 °F
storage temp. 
Inert atmosphere,Room Temperature
Colorless to light yellow liquid
Spicy odor (no threshold data)
Water Solubility 
Stable. Incompatible with strong acids, strong oxidizing agents.
CAS DataBase Reference
680-31-9(CAS DataBase Reference)
EWG's Food Scores
Proposition 65 List
NIST Chemistry Reference
2B (Vol. 15, Sup 7, 71) 1999
EPA Substance Registry System
Hexamethylphosphoramide (680-31-9)
  • Risk and Safety Statements
Signal word  Danger
Hazard statements  H340-H350
Precautionary statements  P201-P308+P313
Hazard Codes  T
Risk Statements  45-46
Safety Statements  53-45-99
RIDADR  2810
WGK Germany  3
RTECS  TD0875000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29299090
Toxicity LD50 in male, female rats (mg/kg): 2650, 3360 orally (Gaines)
NFPA 704
2 0

Hexamethylphosphoramide price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 52730 Hexamethylphosphoramide purum, ≥98.0% (GC) 680-31-9 25ml-f $39.3 2020-08-18 Buy
Sigma-Aldrich 52730 Hexamethylphosphoramide purum, ≥98.0% (GC) 680-31-9 100ml-f $128 2020-08-18 Buy
Sigma-Aldrich 52730 Hexamethylphosphoramide purum, ≥98.0% (GC) 680-31-9 100 mL $132 2021-03-22 Buy
Sigma-Aldrich 52730 Hexamethylphosphoramide purum, ≥98.0% (GC) 680-31-9 25 mL $41.5 2021-03-22 Buy
Sigma-Aldrich 52730 Hexamethylphosphoramide purum, ≥98.0% (GC) 680-31-9 500 mL $294 2021-03-22 Buy

Hexamethylphosphoramide Chemical Properties,Uses,Production

General description

Hexamethylphosphoramide is made from the reaction of dimethylamine and phosphorus oxychloride. It has a molecular weight of 179.2, appearing as colorless or light yellow transparent liquid with slightly astringent taste. It has a relative density of 1.0253~1.0257 (20 ℃), refractive index of 1.4582~1.4589 (20 °C), the freezing point of 2~7 °C and the boiling point of 116~117 °C (1480Pa). It is soluble in polar and non-polar solvents. It is also miscible with the commonly used plasticizers such as dioctyl phthalate, dioctyl sebacate, and triphenyl phosphite in any proportion. It has a similar toxicity to phosphate. Avoid contact with skin. Its containers should be tightly sealed to prevent leakage and water absorption to be deteriorated Hexamethylphosphoramide is the light stabilizer of the PVC, enabling an excellent anti-aging properties of outdoor products with excellent weather resistance, therefore being known as highly-efficient weathering agent of PVC.
Addition of 2 to copies of this product to the PVC film can significantly improve both the weather resistance and cold resistance as well as reducing the processing temperature by 10 °C. This product can also be used as the excellent polar solvent of many kinds of polymer materials such as polyphenylene sulfide, polyurethane and polyamide for improving the resin quality, simplifying the process and reducing costs. Addition it into the ethylene-propylene rubber can improve the flexibility and oil resistance. It can also be used as a co-catalyst for the polymerization of propylene to improve the catalytic efficiency of the main catalyst.

Harmful effects and symptoms of poisoning

To animals: Hexamethylphosphoramide (HMPA) is known to have various kinds of toxic effects on experimental animals. HMPA-induced acute poisoning in rats is characterized with nephropathy, severe bronchiectasis and bronchial pneumonia. Application of HMPA repetitively to rabbit skin can lead to weight loss, changes in gastric function and apparent neurological disorders. Rats subjecting to oral administration of HMPA can exhibit testicular atrophy and semen deficiencies. Small chickens subjecting to oral administration of HMPA can also get highly inhibited growth in its testis. HMPA has been known to induce mutagenesis in Drosophila. However, the effects of HMPA on sex chromosomes in mice showed that the frequency of chromosome aberration induced by HMPA was not significant compared with the control group. Preliminary results of the toxicity study upon inhaling HMPA revealed that nasal tumors will appear in rats after 8 months after being exposed to 400 to 4000 ppb HMPA. In some diseased mice, cancer initiated from the epithelium connecting the nasal bone can fill the nasal cavity and penetrates into the brain. Rats exposed to 50 ppb HMPA didn’t develop nasal cancer compared with the control group.
To humans: the role of HMPA on human toxicity has not been reported.

Protective measures

The traditional measure is that the operator should wear protective clothing, wearing protective glasses and gloves, to avoid direct contact with the product with the production site should be well ventilated.

Chemical properties

It appears as colorless transparent flammable liquid with a medium ammonia flavor. It is soluble in water, polar and non-polar solvents.


1.   It can be used as the efficient anti-corrosion agent of PVC and other kinds of chlorine-containing resin products and coatings.
2.   The product is the weathering solvent of polyvinyl chloride and excellent polar solvent, having a significant effect on the low temperature resistance and aging resistance of the agricultural film; it is a multi-functional high-boiling polar solvent that is aprotic. It can be used as the solvents of polymer synthesis with special effect on the synthesis of polyphenylene sulfide and aromatic polyamide and so on. This product, as the co-catalyst of propylene polymerization catalyst, when supplied to the ethylene propylene rubber, can improve the missile and oil resistance of the latter one. Hexamethylphosphoramide can also be used as a gas chromatographic fixative, ultraviolet inhibitor, rocket fuel additives for lowering the freezing point and chemical sterilizers.
3.   It is effective non-proton solvent; as fixative of gas chromatography (highest usage temperature: 35°C with methanol as the solvent); used for separation and analysis of hydrocarbons; for separation of alkanes, alkenes and alkynes; accelerator of stereo-specific reaction; Ultraviolet inhibitor of PVC.

Production method

It can be obtained through the reaction between dimethylamine and alkali chlorophosphorus. Put the dimethylamine and phosphorus oxychloride for reaction in triethylene glycol as the solvent; control the temperature at 40-60 °C; upon reaction, add ammonia as acid-binding agent with interaction with the generated hydrogen chloride to become ammonium chloride precipitation. After completion of the reaction, filtration was performed. Recycle the trichlorethylene from the filtration and then perform alkali treatment, and then conduct distillation, collecting the fraction of 113-118 °C (2.0kPa) fractions to derive Hexamethylphosphoramide (HMPA). Tsinghua Unisplendour Group Corporation has cooperated with the production plant to develop a new solvent-free process that can achieve a product purity of 99.2% or more. The industrial hexamethylphosphoramide appears as colorless or light yellow transparent liquid. Catalyst grade content ≥ 99.5%; first-class grade ≥ 99.0%; second-class products ≥ 98.0%. Fixed consumption amount of raw materials: dimethylamine 2410kg/t, phosphorus oxychloride: 1610kg/t, liquid ammonia 430kg/t.

Chemical Properties

colourless or light amber liquid with an aromatic spicy odour

Chemical Properties

Hexamethylphosphoric triamide is a colorless liquid with a spicy odor.


Aprotic solvent in organic synthesis. Solvent for polymers, gases; polymerization catalyst; thermal stabilizer in polystyrene; protective additive for polyvinyl and polyolefin resins against uv light degradation. De-icing additive for jet fuels. Chemosterilant for a number of insect pests; chemical mutagen.


Solvent for polymers; polymerization catalyst; stabilizer against thermal degradation in polystyrene; UV stabilizer in polyvinyl and polyolefin resins

General Description

Clear colorless to light amber liquid with a spicy odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

Hexamethylphosphoramide may react with strong oxidizing agents and strong acids . Susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.


Possible carcinogen. Toxic by skin contact. Combustible.

Health Hazard

The acute toxicity of hexamethylphosphoramide is low. HMPA can cause irritation upon contact with the skin and eyes. Hexamethylphosphoramide has been found to cause cancer in laboratory animals exposed by inhalation and meets the criteria for classification as an OSHA "select carcinogen." Chronic exposure to HMPA can cause damage to the lungs and kidneys. Reproductive effects in male animals treated with hexamethylphosphoramide have been observed. HMPA should be regarded as a substance with poor warning properties.

Fire Hazard

Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.

Fire Hazard

Hexamethylphosphoramide is combustible.

Flammability and Explosibility

Combustible liquid. Its decomposition at high temperatures or in a fire can produce phosphine, phosphorus oxides, and oxides of nitrogen, which are extremely toxic. Carbon dioxide or dry chemical extinguishers should be used for HMPA fires.

Potential Exposure

Hexamethylphosphoric triamide is a material possessing unique properties and is widely used as a solvent in small quantities, in organic and organometallic reactions in laboratories. This is the major source of occu pational exposure to HMPA in the United States. It is also used as a processing solvent in the manufacture of aramid fibers. HMPA has been evaluated for use as an ultraviolet light absorber or inhibitor in polyvinylchloride formulations; as an additive for antistatic effects; as a flame retardant; and as a deicing additive for jet fuels. Hexamethylphosphoric triamide has also been extensively investigated as an insect chemosterilant.


Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.


this compound should be handled only in a fume hood, using appropriate impermeable gloves and splash goggles to prevent skin and eye contact. Containers of this substance should be stored in secondary containers.


UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz ardous material, Technical Name Required

Purification Methods

The industrial synthesis is usually by treatment of POCl3 with excess of dimethylamine in isopropyl ether. Impurities are water, dimethylamine and its hydrochloride. It is purified by refluxing over BaO or CaO at about 4mm pressure in an atmosphere of nitrogen for several hours, then distilled from sodium at the same pressure. The middle fraction (b ca 90o) is collected, refluxed over sodium under reduced pressure under nitrogen and distilled. It is kept in the dark under nitrogen, and stored in solid CO2. It can also be stored over 4A molecular sieves. Alternatively, it is distilled under vacuum from CaH2 at 60o and is crystallised twice in a cold room at 0o, seeding the liquid with crystals obtained by cooling in liquid nitrogen. After about two-thirds are frozen, the remaining liquid is drained off [Fujinaga et al. Pure Appl Chem 44 117 1975]. For tests of purity see Fujinaga et al. in Purification of Solvents, Coetzee Ed., Pergamon Press, Oxford, 1982. For efficiency of desiccants in drying HMPA see Burfield and Smithers [J Org Chem 43 3966 1978, Sammes et al. J Chem Soc, Faraday Trans 1 281 1986]. [Beilstein 4 IV 284.] CARCINOGEN.


Incompatible (possibly violent reaction; fire and explosions) with oxidizers (chlorates, nitrates,peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.). Keep away from alkaline materials, chemi cally active metals, strong acids, strong bases.

Waste Disposal

Excess hexamethylphosphoramide and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines.

Hexamethylphosphoramide Preparation Products And Raw materials

Raw materials

Preparation Products

Hexamethylphosphoramide Suppliers

Global( 381)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20010 60
Hangzhou Bayee Chemical Co., Ltd.
0086-571-85775919 China 105 55
career henan chemical co
+86-371-86658258 CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 CHINA 2462 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58
Alchem Pharmtech,Inc.
8485655694 United States 63726 58
0371-55170695 CHINA 26742 58

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View Lastest Price from Hexamethylphosphoramide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-07 Hexamethylphosphoramide
US $20.00 / KG/Tin 1g 99% 50tons per month Wuhan Mulei New Material Technology Co. Ltd
2021-07-13 Hexamethylphosphoramide
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-09 Hexamethylphosphoramide
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Hexamethylphosphoramide Spectrum

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