ChemicalBook CAS DataBase List 2-Bromo-5-nitrobenzotrifluoride

2-Bromo-5-nitrobenzotrifluoride synthesis

6synthesis methods

Product Name:2-Bromo-5-nitrobenzotrifluoride
CAS Number:367-67-9
Molecular formula:C7H3BrF3NO2
Molecular Weight:270

392-83-6

367-67-9

General procedure for the synthesis of 2-bromo-5-nitrobenzotrifluoride from o-bromobenzotrifluoride: 260 g of concentrated sulfuric acid (98%) was placed in a reaction flask at room temperature, and 120 g of fuming nitric acid was added slowly to prepare a nitrification acid mixture. The temperature of the reaction system was maintained at 50-60°C, and 390g of o-bromobenzotrifluoride was slowly added to the mixed acid. After the addition was completed, the temperature was maintained and the reaction continued to be stirred until the GC test showed that the raw material was completely consumed and the reaction was completed. After the reaction solution was left to stratify, the upper organic phase was separated and washed to neutrality with alkali. A bright yellow liquid was obtained, which was immediately post-treated to finally obtain 450.4 g of 2-bromo-5-nitrobenzotrifluoride, with a GC purity of 95% and a yield of 92%.

392-83-6 Synthesis

392-83-6
338 suppliers
$6.00/10g

367-67-9
332 suppliers
$10.00/5G

Yield:367-67-9 92%

Reaction Conditions:

with sulfuric acid;nitric acid at 50 - 60;

Steps:

2.2 (2) nitration reaction

At room temperature and stirring to 260 g concentrated sulfuric acid (98%) slowly add 120 g fuming nitric acid, dubbed nitric acid. 50-60°C to the mixed acid slowly add the product of the next step o-bromotrifluorotoluene 390 g, after adding insulation stir, GC detection has no raw materials that For the end of the reaction. Liquid, the upper organic phase washed by alkali to neutral, washed immediately after the bright yellow liquid liquid 2-bromo-5-nitro-trifluorotoluene 450.4 g, GC content: 95%, yield: 92%.

References:

CN106905104,2017,A Location in patent:Paragraph 0020-0021

393-36-2 Synthesis