ChemicalBook CAS DataBase List 2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine synthesis

2synthesis methods

Product Name:2-Chloro-5-fluoropyrimidine
CAS Number:62802-42-0
Molecular formula:C4H2ClFN2
Molecular Weight:132.52

2-Chloro-5-fluoropyrimidine can be used as a pharmaceutical biochemical intermediate in laboratory research and development processes and chemical production processes.
Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

2927-71-1 Synthesis

2927-71-1
397 suppliers
$6.00/5g

62802-42-0
316 suppliers
$12.00/5g

Yield:62802-42-0 50%

Reaction Conditions:

with acetic acid;zinc in tetrahydrofuran at 70; for 6 h;Heating / reflux;

Steps:

31.A
Step A: 2-Chloro-5-fluoropyrimidine To 2,4-dichloro-5-fluoropyrimidine (15.0 g, 89.8 mmol) is added tetrahydrofuran (100 mL) and zinc powder (17.6 g, 269 mmol). The mixture is heated to 70 ⁰C with vigorous stirring, acetic acid (5.14 mL, 89.8 mmol) is added over Ih and the mixture is heated at reflux for an additional 5h. The mixture is diluted with dichloromethane, filtered through celite, evaporated in vacuo and purified on silica gel to give the desired product (6.00 g, 50 %).

References:

BOEHRINGER INGELHEIM INTERNATIONAL GMBH;BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG WO2007/106705, 2007, A1 Location in patent:Page/Page column 92-93

FullText

6693-08-9 Synthesis

6693-08-9
103 suppliers
$26.00/100mg

62802-42-0
316 suppliers
$12.00/5g

References

2-Chloro-5-fluoropyrimidine Related Search:

5-Fluoropyrimidine Fluorocytosine 2-Chloropyrimidine 2,4-Dichloro-5-fluoropyrimidine (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride 2-Fluoro-3,5-dichloropyridine 6-(1-Bromoethyl)-4-chloro-5-fluoropyrimidine 4,6-Dichloro-5-fluoropyrimidine Pyrimidine, 2-amino-4-chloro-5-fluoro- (7CI,8CI)