2-Methoxy-3-(trifluoromethyl)pyridine synthesis
- Product Name:2-Methoxy-3-(trifluoromethyl)pyridine
- CAS Number:121643-44-5
- Molecular formula:C7H6F3NO
- Molecular Weight:177.12
124-41-4
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65753-47-1
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121643-44-5
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Yield:121643-44-5 89%
Reaction Conditions:
in methanol at 20; for 48 h;
Steps:
2-methoxy-3-trifluoromethylpyridine
2-Chloro-3-trifluoromethyl-pyridine (3 g, 16.53 mmol) was dissolved in 30ml of a solution of sodium methoxide (5.4M) in methanol. The mixture was stirred at ambient temperature for 2 days. After this period of time, the reaction was taken into ice and extracted with DCM three times. The combined extract was washed with brine, dried over magnesium sulfate and concentrated in vacuo to give 2-methoxy-3-trifluoromethyl-pyridine as a light liquid (2.7 g, 89% yield). 1 H-NMR (400 MHz, DMSO-d6, 298 K): ? ppm 3.98 (s, 3H) 7.2 (dd, 1 H) 8.1 1 (d, 1 1-1) 8.45 (d, 1 H). MS: 178.1 [M+1 ]+, Rt(1) =1 .29 min.
References:
WO2013/57711,2013,A1 Location in patent:Page/Page column 45-46
81290-20-2
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121643-44-5
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1628-89-3
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2926-30-9
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121643-44-5
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2926-29-6
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163105-90-6
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121643-44-5
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67-56-1
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124-41-4
717 suppliers
$12.00/25g
65753-47-1
381 suppliers
$8.00/5g
121643-44-5
225 suppliers
$5.00/1g