ChemicalBook CAS DataBase List 2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE

2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE synthesis

9synthesis methods

Product Name:2-(TERT-BUTOXYCARBONYLAMINO)PYRIDINE
CAS Number:38427-94-0
Molecular formula:C10H14N2O2
Molecular Weight:194.23

504-29-0

24424-99-5

38427-94-0

General method: 2-aminopyridine (1 mmol) and di-tert-butyl dicarbonate (1.1 mmol) were placed in a microwave reaction vial. The reaction was carried out using an LG microwave oven MG 555f set at 100°C and 300W. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, ice water was added to the reaction mixture to precipitate tert-butyl pyridin-2-ylcarbamate. The solid product was collected by filtration and washed with excess cold water. The resulting product is pure enough for routine applications. For further characterization, it can be purified by column chromatography using neutral alumina as adsorbent with a solvent ratio of hexane: ethyl acetate (7.5:2.5).

36016-38-3 Synthesis

36016-38-3
363 suppliers
$6.00/5g

38427-94-0
140 suppliers
$10.00/1g

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine / tetrahydrofuran / 0.67 h / -20 °C
2.1: N,O-bis-(trimethylsilyl)-acetamide / 1,4-dioxane / 3 h / 80 °C
2.2: 3 h / 20 °C

References:

Fier, Patrick S.;Kim, Suhong;Cohen, Ryan D. [Journal of the American Chemical Society,2020,vol. 142,# 19,p. 8614 - 8618]

504-29-0
559 suppliers
$5.00/5 g

24424-99-5 Synthesis

24424-99-5
864 suppliers
$13.50/25G

38427-94-0
140 suppliers
$10.00/1g

References