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17881-80-0

2-TRIMETHYLSILYLMETHYLPYRIDINE synthesis

8synthesis methods
-

Yield:17881-80-0 87%

Reaction Conditions:

Stage #1: α-picolinewith 2,2,6,6-tetramethyl-piperidine;n-butyllithium;potassium tert-butylate in hexane;n-heptane at 0; for 0.25 h;Inert atmosphere;
Stage #2: chloro-trimethyl-silane in hexane;n-heptane at 0; for 1 h;Inert atmosphere;

References:

Manvar, Atul;Fleming, Patricia;O'Shea, Donal F. [Journal of Organic Chemistry,2015,vol. 80,# 17,p. 8727 - 8738]