ChemicalBook CAS DataBase List 4-CHLOROCARBONYLPHENYLBORONIC ACID PROPANEDIOL ESTER

4-CHLOROCARBONYLPHENYLBORONIC ACID PROPANEDIOL ESTER synthesis

5synthesis methods

Product Name:4-CHLOROCARBONYLPHENYLBORONIC ACID PROPANEDIOL ESTER
CAS Number:380499-68-3
Molecular formula:C13H16BClO3
Molecular Weight:266.53

79-37-8
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$17.67/10gm:

180516-87-4 Synthesis

4-Carboxylphenylboronic acid pinacol ester

180516-87-4
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$8.00/1g

4-CHLOROCARBONYLPHENYLBORONIC ACID PROPANEDIOL ESTER

380499-68-3
25 suppliers
$495.39/5MG

Yield:380499-68-3 21.5 g

Reaction Conditions:

in dichloromethane;N,N-dimethyl-formamide at 0 - 20; for 2.33333 h;

Steps:

1 Intermediate 8: N-(pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide

20 g of 4- (4,4,5,5-tetramethyl-1,3,2-dioxolane-2-yl) benzoic acid is dissolved in 350 ml of dichloromethane,Cool down to 0-5 ° C.Add 1 ml of DMF, dropwise add 16 ml of oxalyl chloride, and stir at 0-5 ° C for 20 min; warm to room temperature and stir for 2 hr.The reaction solution was concentrated and stripped twice with dichloromethane.21.5 g of acid chloride were obtained and used directly in the next reaction.

References:

CN110563733,2019,A Location in patent:Paragraph 0098-0100; 0112-0113

180516-87-4 Synthesis

180516-87-4
224 suppliers
$8.00/1g

380499-68-3
25 suppliers
$495.39/5MG

References

76-09-5 Synthesis