ChemicalBook CAS DataBase List 4-BROMO-2-CHLOROBENZOIC ACID METHYL ESTER

4-BROMO-2-CHLOROBENZOIC ACID METHYL ESTER synthesis

7synthesis methods

Product Name:4-BROMO-2-CHLOROBENZOIC ACID METHYL ESTER
CAS Number:185312-82-7
Molecular formula:C8H6BrClO2
Molecular Weight:249.49

59748-90-2 Synthesis

59748-90-2
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4-BROMO-2-CHLOROBENZOIC ACID METHYL ESTER

185312-82-7
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Yield: 94%

Reaction Conditions:

with hydrogenchloride in methanol;diethyl ether

Steps:

3.A A.
A. 4-Bromo-2-chloro benzoic acid, methyl ester Hydrochloric acid (gas) was bubbled through a solution of 10 g (42.5 mmol) of 4-bromo-2-chloro benzoic acid in 100 ml of methanol until reflux occurred. The resulting reaction mixture was allowed to react overnight. When the reaction was substantially complete, as indicated by TLC, the reaction mixture was concentrated in vacuo to provide a residue. This residue was redissolved in diethyl ether and washed sequentially with water (twice) and a saturated sodium chloride solution, dried over sodium sulfate, filtered and then concentrated in vacuo to provide 10 g of a light tan oil. Yield: 94%.

References:

Eli Lilly and Company US5786325, 1998, A

59748-90-2 Synthesis

59748-90-2
273 suppliers
$8.00/1g