(4'-O-methyl)methyl gallate synthesis
- Product Name:(4'-O-methyl)methyl gallate
- CAS Number:24093-81-0
- Molecular formula:C9H10O5
- Molecular Weight:198.17
149-91-7
725 suppliers
$5.00/25g
74-88-4
351 suppliers
$15.00/10g
1916-07-0
443 suppliers
$6.00/25g
24093-81-0
54 suppliers
$45.00/10mg
83011-43-2
135 suppliers
$50.00/250mg
Yield:24093-81-0 61% ，83011-43-2 14% ，1916-07-0 10%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 0 - 20;
Steps:
General procedure of methylation of gallic acid
General procedure: To the gallic acid solution in DMF at 0° C,K2CO3 and MeI were added. The reaction mixture is stirred at 0°C and allowed to reach at room temperature overnight, with a total reaction time of 18-24 hours. The reaction mixture is then diluted byaddition of ethylacetate, and washed repeatedly with saturated NaHCO3 solution. The ethylacetate phase is then washed further with a saturated NaCl(Brine) solution to withdraw residual water, then dried with anhydrous MgSO4, filtered, and concentrated, resulting in a crude extract of methylated product. Furthermore, the crude extract is purified by silica gel chromatography column. Pure compounds were analyzed by Thin Layer Chromatography (TLC), Nuclear Magnetic Resonance Spectrometer, and High Resolution Mass Spectrometer
References:
Arsianti, Ade;Astuty, Hendri;Fadilah;Simadibrata, Daniel Martin;Adyasa, Zoya Marie;Amartya, Daniel;Bahtiar, Anton;Tanimoto, Hiroki;Kakiuchi, Kiyomi [Oriental Journal of Chemistry,2018,vol. 34,# 2,p. 655 - 662]
99-24-1
444 suppliers
$10.00/5g
74-88-4
351 suppliers
$15.00/10g
24093-81-0
54 suppliers
$45.00/10mg
13089-97-9
0 suppliers
inquiry
24093-81-0
54 suppliers
$45.00/10mg
99-24-1
444 suppliers
$10.00/5g
77-78-1
322 suppliers
$19.69/1ml
24093-81-0
54 suppliers
$45.00/10mg
99-24-1
444 suppliers
$10.00/5g
74-88-4
351 suppliers
$15.00/10g
24093-81-0
54 suppliers
$45.00/10mg
83011-43-2
135 suppliers
$50.00/250mg