5-[(2-Hydroxyethyl)amino]-o-cresol synthesis

Yield:55302-96-0 94.1%

Reaction Conditions:

with NaY in diethylene glycol dimethyl ether at 150; for 3.5 h;Green chemistry;Reagent/catalyst;Solvent;

Steps:

4
In a 250 ml four-necked flask equipped with a thermometer, stirrer,A solution of 12.3 g (0.1 mol) of 5-amino-2-methylphenol in 80 ml of diethylene glycol dimethyl ether was added to a temperature of 150 ° C and stirred slowly in a cold trap to introduce 4.4 g (0.1 mol) of ethylene oxide in 10 ml of diethylene glycol dimethyl ether, 0.3 g of NaY molecular sieve catalyst was added to a four-necked flask and the mixture was added dropwise. After dropping for 0.5 h, the reaction was carried out for 3 hours and the reaction solution The solvent was distilled off under reduced pressure, and after drying, the residue was cooled to obtain 16.6 g of crude product of 5- (2-hydroxyethyl) amino o-cresol and added to 100 ml of methanol-water to recrystallize to give 5- (2-hydroxyethyl) Amino-o-cresol refined product 15.7g, yield 94.1%, purity 99.52%.

References:

Zhejiang Dinglong Technology Co., Ltd.;Jiangsu Dinglong Technology Co., Ltd.;Xu Huigang;Pan Zhijun;Jin Ningren;Gu Fenglei;Liu Feng;Huang Wei;Ye Jiongying CN106588678, 2017, A Location in patent:Paragraph 0025; 0026; 0028; 0030; 0031; 0032; 0034

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