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ChemicalBook CAS DataBase List 5-Aminolevulinic acid

5-Aminolevulinic acid synthesis

5synthesis methods
-

Yield:106-60-5 81.7%

Reaction Conditions:

with hydrogenchloride in water at 110; for 12 h;

Steps:

1.4; 2.4; 3.4; 4.4 (4) Hydrolysis reaction

0.65 g of 5-PhMLA and 20 mL of 7 mol / L hydrochloric acid were placed in a round-bottomed flask, and the reaction was performed at a temperature of 110 ° C for 12 hours. After the reaction was completed, the reaction solution was cooled to room temperature and then placed at -22 ° C for 3 hours. The filtrate was collected, distilled under reduced pressure (90 kPa), concentrated, and acetone was added to the concentrated solution to obtain 5-ALA white crystal particles. The 5-ALA yield was determined to be 81.7%.c

References:

CN110330440,2019,A Location in patent:Paragraph 0025; 0033-0036; 0043-0045; 0052-0054; 0061-0062

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