2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid diethyl ester synthesis
- Product Name:2,2,14,14-Tetramethyl-8-oxopentadecanedioic acid diethyl ester
- CAS Number:738606-43-4
- Molecular formula:C23H42O5
- Molecular Weight:398.58
36635-61-7
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Yield:738606-43-4 53%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide;sodium hydride in dimethyl sulfoxide at 20; for 12 h;Inert atmosphere;
Steps:
1.2 Step 2 Synthesis of Compound 5
Under 0 °C nitrogen protection conditions,Sodium hydride (0.3 g, 12.4 mmol) was slowly added to compound 3 (3.0 g, 11.3 mmol),a solution of tetrabutyl iodide (0.42 g, 1.13 mmol) and compound 4 (1.1 g, 5.63 mmol) in DMSO (20 mL)After the addition, the reaction was carried out at room temperature for 12 h.The reaction was quenched by the addition of ice water (40 ml).Extracted with dichloromethane (50 ml × 3), combined organic phase,Dry over anhydrous sodium sulfate and concentrate to about 30 ml of solvent.Concentrated hydrochloric acid (15 ml) was added and stirred at room temperature for 2 h.Then separate the organic phase,Wash with sodium bicarbonate solution, remove the solvent,The concentrate was subjected to column separation (eluent: petroleum ether: ethyl acetate = 20:1).1.2 g of a colorless liquid was obtained in a yield of 53%.
References:
CN110054562,2019,A Location in patent:Paragraph 0161; 0164; 0167; 0168
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738606-44-5
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111-24-0
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738606-43-4
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97-62-1
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738606-43-4
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123469-92-1
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738606-43-4
115 suppliers
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