ChemicalBook CAS DataBase List 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid synthesis

4synthesis methods

Product Name:5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid
CAS Number:800401-68-7
Molecular formula:C8H5ClN2O2
Molecular Weight:196.59

800401-67-6 Synthesis

ethyl 5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylate

800401-67-6
102 suppliers
$98.00/50mg

5-chloro-1H-pyrrolo[2,3-c]pyridine-2-carboxylic acid

800401-68-7
81 suppliers
$65.00/50 mg

Yield: 71%

Reaction Conditions:

with sodium hydroxide in ethanol for 2 h;Reflux;

Steps:

3.1.6. General Procedure for the Preparation of 1H-pyrrolo[2,3-c]pyridine-2-carboxylic Acids 10a-d
General procedure: To a stirred solution of 9a-d (1.3 mmol) in EtOH (12 mL) 2M NaOH was added (1.7 mmol, 1.1 mL).The reaction mixture was heated under reflux for 1h (10a) or 2h (10b) and the solvent was evaporated.Water (10 mL) was added and acetic acid was added until pH 4.0. The desired product was filtered off,dried into the desiccators to afford the desired product.

References:

Parrino, Barbara;Span, Virginia;Carbone, Anna;Barraja, Paola;Diana, Patrizia;Cirrincione, Girolamo;Montalbano, Alessandra [Molecules,2014,vol. 19,# 9,p. 13342 - 13357]

127-17-3 Synthesis