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87014-28-6

Benzene, 1-nitro-2-(2,2,2-trifluoroethoxy)- synthesis

10synthesis methods
-

Yield:87014-28-6 99%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 20; for 16 h;

Steps:

243.1

[00501] Step .1 : A mixture of 2-iiitraphenol ( 1 .39 g, 10 mmol), CF3CH2OTf (3.48 g, 15 mmol,, i .5 eq) and CS2CO3 (6.5 g. 20 mmol, 2.0 eq) in 10 mi, ofDMF was stirred at it for 16 h. The mixture was diluted with 150 niL of EtOAc and washed with water (100 niL*2) and brine (100 ml). The organic was dried and concenirated in vacuo to give 243a (2.2 g, 99%) as yellow solid, which was used to the next step without further purification. ESI- S (M+H)+: 222.1 . }H NM (400 MHz, COC ) δ: 7.89 (d, J - 8.4 Hz, 1 H). 7.59-7.56 (ra, 1H), 7.23-7.18 (m, l H), 7.13 (d, J - 8.4 Hz, 1H), 4.49 (q, J ' = 8.0 l, 2H).

References:

WO2014/8214,2014,A1 Location in patent:Paragraph 00500-00501