ChemicalBook CAS DataBase List Benzethonium chloride

Benzethonium chloride synthesis

5synthesis methods

Product Name:Benzethonium chloride
CAS Number:121-54-0
Molecular formula:C27H42ClNO2
Molecular Weight:448.08

p-Diisobutylphenol is condensed in the presence of a basic catalyst with β,β'-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.

103-83-3 Synthesis

103-83-3
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65925-28-2 Synthesis

1-[2-(2-chloroethoxy)ethoxy]-4-(1,1,3,3-tetramethylbutyl)benzene

65925-28-2
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121-54-0
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Yield:121-54-0 731 kg

Reaction Conditions:

in water monomer at 115; for 7 h;Inert atmosphere;Large scale;

Steps:

1.2-3.2

(2) Put 450kg of compound A, 200kg of benzyl dimethylamine and 330kg of water into the reaction kettle, start stirring, nitrogen replacement, nitrogen protection, heat up to 115 ° C, continue the reaction for 7h, cool down, discharge, transfer to dehydration The kettle was then added with 400kg of toluene, heated to reflux, dehydrated, dehydrated, frozen and crystallized, suction filtered, dried, recrystallized with 1000kg of acetone again, cooled, crystallized, suction filtered, dried to obtain 731kg of benzethonium chloride , the purity is 99.3%.

References:

CN114031511,2022,A Location in patent:Paragraph 0011-0016