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Benzethonium chloride

Benzethonium chloride
Benzethonium chloride structure
CAS No.
121-54-0
Chemical Name:
Benzethonium chloride
Synonyms
1622;diapp;disilyn;sanizol;HYAMINE;SOLAMIN;banagerm;solamine;inactisol;phemithyn
CBNumber:
CB9382932
Molecular Formula:
C27H42ClNO2
Formula Weight:
448.08
MOL File:
121-54-0.mol

Benzethonium chloride Properties

Melting point:
162-164 °C (lit.)
Density 
0.998 g/mL at 20 °C
vapor pressure 
< 0.001 hPa @ 2°C
refractive index 
1.5650 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 0.1 M at 20 °C, clear, colorless
form 
Liquid
color 
White
PH
5.5-7.5 (25℃, 0.1M in H2O)
Odor
Odorless
PH Range
5.5 - 7.5
Water Solubility 
1-5 g/100 mL at 18 ºC
Sensitive 
Hygroscopic
Merck 
14,1074
BRN 
3898548
Stability:
Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents, soap, anionic detergents, nitrates, acids. Light sensitive.
CAS DataBase Reference
121-54-0(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
BENZETHONIUM CHLORIDE
FDA 21 CFR
175.105; 310.545
EWG's Food Scores
4-6
FDA UNII
PH41D05744
EPA Substance Registry System
Benzethonium chloride (121-54-0)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS05,GHS06,GHS09,GHS07
Signal word  Danger
Hazard statements  H412-H301-H314-H410-H302-H315-H319-H318-H400
Precautionary statements  P264-P270-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P273-P280-P301+P310-P305+P351+P338-P310-P501-P260-P303+P361+P353-P304+P340+P310-P260h-P301+P330+P331-P405-P501a
Hazard Codes  Xn,N,C
Risk Statements  22-37/38-41-36-36/37/38-20/21/22-50/53-34-52/53
Safety Statements  26-36/39-24/25-36/37/39-61-45
RIDADR  UN1759
WGK Germany  2
RTECS  BO7175000
8
TSCA  Yes
HazardClass  8
PackingGroup  III
HS Code  29239000
Toxicity LD50 i.v. in mice: 29.5 mg/kg (Weiss)

Benzethonium chloride price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 51126 Hyamine? 1622 solution 4 mM in H2O 121-54-0 1l-f $47.6 2020-08-18 Buy
Sigma-Aldrich 1.15480 Hyamine® 1622-solution for the determination of anionic tensides 0.004 mol/l Titripur? 121-54-0 1003 $57.16 2021-03-22 Buy
Sigma-Aldrich 1.15480 Hyamine® 1622-solution for the determination of anionic tensides 0.004 mol/l Titripur? 121-54-0 1 L $61.88 2021-03-22 Buy
Sigma-Aldrich B0550000 Benzethonium chloride European Pharmacopoeia (EP) Reference Standard 121-54-0 $190 2021-03-22 Buy
Sigma-Aldrich 1051500 Benzethonium chloride United States Pharmacopeia (USP) Reference Standard 121-54-0 500mg $366 2021-03-22 Buy

Benzethonium chloride Chemical Properties,Uses,Production

Chemical Properties

White or yellowish-white powder.

Chemical Properties

Benzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.

Originator

Phemerol,Parke Davis,US,1942

Uses

benzethonium chloride is a preservative that works against algae, bacteria, and fungi. In skin care preparations, it is safe for use at concentrations of 0.5 percent.

Uses

antiinfective (topical)

Uses

A synthetic quaternary ammonium salt with surfactant, antiseptic and anti-infective properties. It exhibits microbiocidal activity against a broad range of bacteria, fungi, mold and viruses. It has al so been found to have significant broad-spectrum anticancer activity.

Uses

In cosmetics as preservative; cationic surfactant. As disinfectant in dairies and food industries. Clinical reagent for determination of protein in CSF; pharmaceutic aid (preservative).

Uses

Benzethonium Chloride USP is used as germicide for pharmaceutical and cosmetic products. (USP grade of Hyamine(R) 1622 crystals).

Uses

The cationic detergent benzethonium chloride is a well characterized skin irritant and rare sensitizer. Benzethonium chloride has been used in a study to assess the minimum inhibitory concentrations of meticillin-resistant Staphylococcus aureus (MRSA) isolates from Malaysia. It has also been used in a study to prepare biocomposite films from sodium alginate and modified clay.

Uses

Hyamine(R) 1622 Crystals is a FDA accepted ingredient for topical applications. It can be used as a bactericide, deodorant, or as a preservative in various applications including those in personal care, veterinary and pharmaceutical.

Definition

ChEBI: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it i active against a broad spectrum of bacteria, fungi, moulds and viruses.

Production Methods

p-Diisobutylphenol is condensed in the presence of a basic catalyst with β,β'-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.

Manufacturing Process

A mixture of 32 g of p-(α,α,γ,γ-tetramethylbutyl)phenoxyethoxyethyldimethylamine and 12.7 parts of benzyl chloride was warmed in 50 g of benzene for 2 hours. The benzene was then evaporated. The residual viscous mass gave a foamy, soapy solution in water. The original starting materials are p-diisobutylphenol, dichlorodiethyl ether and dimethylamine.

brand name

Microklenz (Carrington); Phemerol Chloride (Parke-Davis).

Therapeutic Function

Topical antiinfective

General Description

Odorless white crystals or powder with a very bitter taste. A 1% solution in water is slightly alkaline to litmus.

Air & Water Reactions

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble.

Reactivity Profile

Benzethonium chloride is incompatible with strong oxidizing agents Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause Benzethonium chloride to precipitate from aqueous solutions of >2% concentration. Stable for two weeks at temperatures up to 140 F, .

Hazard

An oral poison.

Fire Hazard

Flash point data for Benzethonium chloride are not available. Benzethonium chloride is probably combustible.

Pharmaceutical Applications

Benzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant.
In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v.
The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.

Safety Profile

Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes. Asevere eye irritant. Questionable carcinogen withexperimental neoplastigenic data. Mutation data reported.When heated to decomposition it emits very toxic fumesof Cl -

Safety

Benzethonium chloride is readily absorbed and is generally regarded as a toxic substance when administered orally. Ingestion may cause vomiting, collapse, convulsions, and coma. The probable lethal human oral dose is estimated to be 50–500 mg/kg bodyweight.
The topical use of solutions containing greater than 5% w/v benzethonium chloride can cause irritation although benzethonium chloride is not regarded as a sensitizer. The use of 0.5% w/v benzethonium chloride in cosmetics is associated with few adverse effects. A maximum concentration of 0.02% w/v benzethonium chloride is recommended for use in cosmetics used in the eye area and this is also the maximum concentration generally used in pharmaceutical formulations such as injections and ophthalmic preparations.
See also Benzalkonium Chloride.
LD50 (mouse, IP): 15.5 mg/kg
LD50 (mouse, IV): 30 mg/kg
LD50 (mouse, oral): 338 mg/kg
LD50 (rat, IP): 16.5 mg/kg
LD50 (rat, IV): 19 mg/kg
LD50 (rat, oral): 368 mg/kg
LD50 (rat, SC): 119 mg/kg

storage

Benzethonium chloride is stable. Aqueous solutions may be sterilized by autoclaving.
The bulk material should be stored in an airtight container protected from light, in a cool, dry place.

Purification Methods

Crystallise it from boiling acetone after filtering or from CHCl3/pet ether. The precipitate is filtered off, washed with diethyl ether and dried for 24hours in a vacuum desiccator. It is a cationic antiseptic surfactant which forms crystals also from a 1:9 MeOH/Et2O mixture. It foams in water. [Beilstein 12 IV 2187.]

Incompatibilities

Benzethonium chloride is incompatible with soaps and other anionic surfactants and may be precipitated from solutions greater than 2% w/v concentration by the addition of mineral acids and some salt solutions.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM and IV injections; nasal, ophthalmic and otic preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Benzethonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products


Benzethonium chloride Suppliers

Global( 391)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 3001 55
Guangzhou Lily New Materials Co.,Ltd.
86-020-38686255
86-020-38686255 info@lilychems.com CHINA 38 58
CD Chemical Group Limited
+8613651442114
0086-13651442114 info@codchem.com China 20384 58
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 sales@frappschem.com China 886 50
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View Lastest Price from Benzethonium chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-18 Benzethonium chloride
121-54-0
US $47.00 / KG 1000KG 97%-103% 30tons Guangzhou Lily New Materials Co.,Ltd.
2021-09-29 Benzethonium chloride
121-54-0
US $0.00 / Kg/Drum 1KG 97%-103% 1000kgs WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-02 Benzethonium chloride
121-54-0
US $10.00 / KG 100KG 99% 100 mt Hebei Guanlang Biotechnology Co., Ltd.

Benzethonium chloride Spectrum


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