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Benzethonium chloride

Benzethonium chloride
Benzethonium chloride structure
Chemical Name:
Benzethonium chloride
Molecular Formula:
Formula Weight:
MOL File:

Benzethonium chloride Properties

Melting point:
162-164 °C(lit.)
0.998 g/mL at 20 °C
refractive index 
1.5650 (estimate)
storage temp. 
Store at +15°C to +25°C.
H2O: 0.1 M at 20 °C, clear, colorless
5.5-7.5 (25℃, 0.1M in H2O)
Water Solubility 
1-5 g/100 mL at 18 ºC
Stability Stable, but hygroscopic. Incompatible with strong oxidizing agents, soap, anionic detergents, nitrates, acids. Light sensitive.
CAS DataBase Reference
121-54-0(CAS DataBase Reference)
EPA Substance Registry System
Benzenemethanaminium, N,N-dimethyl-N-[2-[2-[4-(1, 1,3,3-tetramethylbutyl)phenoxy] ethoxy]ethyl]-, chloride(121-54-0)
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,N,C
Risk Statements  22-37/38-41-36-36/37/38-20/21/22-50/53-34-52/53
Safety Statements  26-36/39-24/25-36/37/39-61-45
WGK Germany  2
RTECS  BO7175000
HazardClass  8
PackingGroup  III
HS Code  29239000
Hazardous Substances Data 121-54-0(Hazardous Substances Data)
Toxicity LD50 i.v. in mice: 29.5 mg/kg (Weiss)
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
H412 Harmful to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 3 P273, P501
Precautionary statements:
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.
P501 Dispose of contents/container to..…

Benzethonium chloride price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 51126 Hyamine? 1622 solution 4 mM in H2O 121-54-0 1l-f $45.6 2018-11-13 Buy
Sigma-Aldrich 1051500 Benzethonium chloride United States Pharmacopeia (USP) Reference Standard 121-54-0 500mg $348 2018-11-13 Buy
TCI Chemical B0044 Benzethonium Chloride >97.0%(HPLC) 121-54-0 25g $18 2018-11-22 Buy
TCI Chemical B0044 Benzethonium Chloride >97.0%(HPLC) 121-54-0 100g $36 2018-11-22 Buy
Alfa Aesar A16142 Benzethonium chloride, 97% 121-54-0 100g $39.4 2018-11-13 Buy

Benzethonium chloride Chemical Properties,Uses,Production

Chemical Properties

White or yellowish-white powder.

Chemical Properties

Benzethonium chloride occurs as a white crystalline material with a mild odor and very bitter taste.


benzethonium chloride is a preservative that works against algae, bacteria, and fungi. In skin care preparations, it is safe for use at concentrations of 0.5 percent.


antiinfective (topical)


A synthetic quaternary ammonium salt with surfactant, antiseptic and anti-infective properties. It exhibits microbiocidal activity against a broad range of bacteria, fungi, mold and viruses. It has al so been found to have significant broad-spectrum anticancer activity.


In cosmetics as preservative; cationic surfactant. As disinfectant in dairies and food industries. Clinical reagent for determination of protein in CSF; pharmaceutic aid (preservative).


Benzethonium Chloride USP is used as germicide for pharmaceutical and cosmetic products. (USP grade of Hyamine(R) 1622 crystals).


Hyamine(R) 1622 50% is a FDA accepted ingredient for topical applications. It can be used as a bactericide, deodorant, or as a preservative in various applications including those in personal care, veterinary and pharmaceutical.


Hyamine(R) 1622 Crystals is a FDA accepted ingredient for topical applications. It can be used as a bactericide, deodorant, or as a preservative in various applications including those in personal care, veterinary and pharmaceutical.


ChEBI: A (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. An antiseptic and disinfectant, it i active against a broad spectrum of bacteria, fungi, moulds and viruses.

Production Methods

p-Diisobutylphenol is condensed in the presence of a basic catalyst with β,β'-dichlorodiethyl ether to yield 2-[2-[4-(1,1,3,3-tetramethylbutyl) phenoxy]ethoxy]ethyl chloride. Alkaline dimethylamination then produces the corresponding tertiary amine which, after purification by distillation, is dissolved in a suitable organic solvent and treated with benzyl chloride to precipitate benzethonium chloride.

brand name

Microklenz (Carrington); Phemerol Chloride (Parke-Davis).

General Description

Odorless white crystals or powder with a very bitter taste. A 1% solution in water is slightly alkaline to litmus.

Air & Water Reactions

Hygroscopic. May be sensitive to prolonged exposure to air. Water soluble.

Reactivity Profile

Benzethonium chloride is incompatible with strong oxidizing agents Incompatible with soap and anionic detergents. Can react with nitrates. Sensitive to light. Acids cause Benzethonium chloride to precipitate from aqueous solutions of >2% concentration. Stable for two weeks at temperatures up to 140 F, .


An oral poison.

Fire Hazard

Flash point data for Benzethonium chloride are not available. Benzethonium chloride is probably combustible.

Pharmaceutical Applications

Benzethonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative. Typically, it is used for this purpose in injections, ophthalmic and otic preparations at concentrations 0.01–0.02% w/v. Benzethonium chloride may also be used as a wetting and solubilizing agent, and as a topical disinfectant.
In cosmetics such as deodorants, benzethonium chloride may be used as an antimicrobial preservative in concentrations up to 0.5% w/v.
The physical properties and applications of benzethonium chloride are similar to those of other cationic surfactants such as cetrimide.


Benzethonium chloride is readily absorbed and is generally regarded as a toxic substance when administered orally. Ingestion may cause vomiting, collapse, convulsions, and coma. The probable lethal human oral dose is estimated to be 50–500 mg/kg bodyweight.
The topical use of solutions containing greater than 5% w/v benzethonium chloride can cause irritation although benzethonium chloride is not regarded as a sensitizer. The use of 0.5% w/v benzethonium chloride in cosmetics is associated with few adverse effects. A maximum concentration of 0.02% w/v benzethonium chloride is recommended for use in cosmetics used in the eye area and this is also the maximum concentration generally used in pharmaceutical formulations such as injections and ophthalmic preparations.
See also Benzalkonium Chloride.
LD50 (mouse, IP): 15.5 mg/kg
LD50 (mouse, IV): 30 mg/kg
LD50 (mouse, oral): 338 mg/kg
LD50 (rat, IP): 16.5 mg/kg
LD50 (rat, IV): 19 mg/kg
LD50 (rat, oral): 368 mg/kg
LD50 (rat, SC): 119 mg/kg


Benzethonium chloride is stable. Aqueous solutions may be sterilized by autoclaving.
The bulk material should be stored in an airtight container protected from light, in a cool, dry place.

Purification Methods

Crystallise it from boiling acetone after filtering or from CHCl3/pet ether. The precipitate is filtered off, washed with diethyl ether and dried for 24hours in a vacuum desiccator. It is a cationic antiseptic surfactant which forms crystals also from a 1:9 MeOH/Et2O mixture. It foams in water. [Beilstein 12 IV 2187.]


Benzethonium chloride is incompatible with soaps and other anionic surfactants and may be precipitated from solutions greater than 2% w/v concentration by the addition of mineral acids and some salt solutions.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM and IV injections; nasal, ophthalmic and otic preparations). Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Benzethonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Benzethonium chloride Suppliers

Global( 245)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
JingJiang Connect Chemical manufacturing Co., Ltd.
0523-80501690 15252623102
0523-84506952 CHINA 59 55
Frapp's ChemicalNFTZ Co., Ltd.
+86 (576) 8169-6106
+86 (576) 8169-6105 China 886 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817 CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733 CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 1750 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114 CHINA 6374 58
Hebei Chisure Biotechnology Co., Ltd.
+8613091036086; +8613292890173
+8613292893290; CHINA 1019 58
career henan chemical co
+86-371-86658258 CHINA 20516 58

View Lastest Price from Benzethonium chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-17 Benzethonium chloride
US $1.00 / kg 1kg 99% Customized career henan chemical co

Benzethonium chloride Spectrum

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