Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Benzyl 4-hydroxy-1-piperidinecarboxylate
95798-23-5

Benzyl 4-hydroxy-1-piperidinecarboxylate synthesis

8synthesis methods
4-Hydroxypiperidine

5382-16-1

Benzyl chloroformate

501-53-1

Benzyl 4-hydroxy-1-piperidinecarboxylate

95798-23-5

General procedure for the synthesis of N-Benzyloxycarbonyl-4-hydroxypiperidine from 4-hydroxypiperidine and benzyl chloroformate: over 30 min, benzyl chloroformate (8.55 mL; 60 mmol) was slowly added dropwise to a well-stirred 4-hydroxypiperidine (5 g; 49.44 mmol), a 1N aqueous NaOH solution (60 mL; 60 mmol) and dioxane (60 mL) in a in a cooled mixture. After dropwise addition, the reaction mixture was continued to stir for 30 minutes. Upon completion of the reaction, the reaction mixture was treated with water and subsequently concentrated and acidified with hydrochloric acid to pH 2. The acidified aqueous phase was extracted with EtOAc, the organic phases were combined, washed with water and saturated brine in that order, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by fast column chromatography (silica gel was the stationary phase, and the eluents were petroleum ether with 50% dichloromethane (60-80 °C) and 10% acetonitrile containing 2% methanol in chloroform solution). The final product was 12.5 g (99% yield) of N-Cbz-4-hydroxypiperidine as an oil; mass spectrum (chemical ionization): m/z 236 (M++1), 218, 192, 174, 91.

19099-93-5 Synthesis
 1-Cbz-4-Piperidone

19099-93-5
0 suppliers
$5.00/1g

-

Benzyl 4-hydroxy-1-piperidinecarboxylate Related Search: