ChemicalBook CAS DataBase List BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE

BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE synthesis

7synthesis methods

Product Name:BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE
CAS Number:1020-16-2
Molecular formula:C13H18ClNO2
Molecular Weight:255.74

110-91-8 Synthesis

110-91-8
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50-00-0 Synthesis

50-00-0
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98-86-2 Synthesis

98-86-2
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BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE

1020-16-2
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Yield: 75%

Reaction Conditions:

with hydrogenchlorideReflux;Mannich Aminomethylation;

Steps:

3.1. General procedure for synthesis of Mannich bases
General procedure: Mannich bases were synthesized according to the given literature procedure. 23 A mixture of paraformaldehyde(1.80 g, 1.2 eq., 60.0 mmol), ketone (1.0 eq., 50.0 mmol), morpholine (4.35 g, 1.0 eq., 50.0 mmol), andhydrochloric acid (1.0 eq., 50.0 mmol) in ethanol was stirred at refl ux. The reaction was monitored by TLC.After the completion of the reaction, crude product was fi ltered and recrystallized in ethanol.3-Morpholino-1-phenylpropan-1-one hydrochloride (1a): White solid; mp 177-178 °C (lit. 175-178 °C); yield: 75%. 24

References:

Seyi̇Tdanlioğlu, Pınar;Hanashalshahaby, Essam Hamied Ahmed;Ünaleroğlu, Canan [Turkish Journal of Chemistry,2018,vol. 42,# 6,p. 1598 - 1610]

50-00-0 Synthesis

50-00-0
840 suppliers
$10.00/25g