BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE synthesis
- Product Name:BETA-(4-MORPHOLINO)PROPIOPHENONE HYDROCHLORIDE
- CAS Number:1020-16-2
- Molecular formula:C13H18ClNO2
- Molecular Weight:255.74
110-91-8
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98-86-2
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1020-16-2
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$22.19/5g
Yield: 75%
Reaction Conditions:
with hydrogenchlorideReflux;Mannich Aminomethylation;
Steps:
3.1. General procedure for synthesis of Mannich bases
General procedure: Mannich bases were synthesized according to the given literature procedure. 23 A mixture of paraformaldehyde(1.80 g, 1.2 eq., 60.0 mmol), ketone (1.0 eq., 50.0 mmol), morpholine (4.35 g, 1.0 eq., 50.0 mmol), andhydrochloric acid (1.0 eq., 50.0 mmol) in ethanol was stirred at refl ux. The reaction was monitored by TLC.After the completion of the reaction, crude product was fi ltered and recrystallized in ethanol.3-Morpholino-1-phenylpropan-1-one hydrochloride (1a): White solid; mp 177-178 °C (lit. 175-178 °C); yield: 75%. 24
References:
Seyi̇Tdanlioğlu, Pınar;Hanashalshahaby, Essam Hamied Ahmed;Ünaleroğlu, Canan [Turkish Journal of Chemistry,2018,vol. 42,# 6,p. 1598 - 1610]
50-00-0
891 suppliers
$10.00/25g
10024-89-2
130 suppliers
$5.00/5g
98-86-2
795 suppliers
$9.00/5g
1020-16-2
28 suppliers
$22.19/5g
108-86-1
517 suppliers
$10.00/5g
1020-16-2
28 suppliers
$22.19/5g
110-88-3
254 suppliers
$10.00/25g
10024-89-2
130 suppliers
$5.00/5g
98-86-2
795 suppliers
$9.00/5g
1020-16-2
28 suppliers
$22.19/5g