
Bexarotene synthesis
- Product Name:Bexarotene
- CAS Number:153559-49-0
- Molecular formula:C24H28O2
- Molecular Weight:348.48
Wagner, Carl E.; Jurutka, Peter W.; Marshall, Pamela A.; Groy, Thomas L.; van der Vaart, Arjan; Ziller, Joseph W.; Furmick, Julie K.; Graeber, Mark E.; Matro, Erik; Miguel, Belinda V.; Tran, Ivy T.; Kwon, Jungeun; Tedeschi, Jamie N.; Moosavi, Shahram; Danishyar, Amina; Philp, Joshua S.; Khamees, Reina O.; Jackson, Jevon N.; Grupe, Darci K.; Badshah, Syed L.; Hart, Justin W. Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene). Journal of Medicinal Chemistry. Division of Mathematical and Natural Sciences, New College of Interdisciplinary Arts and Sciences. Arizona State University. Glendale, USA 85306. Volume 52. Issue 19. Pages 5950-5966. 2009

110-03-2
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153559-49-0
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$25.00/5mg
Yield:-
Steps:
Multi-step reaction with 7 steps
1: HCl conc. / 3 h / 20 °C
2: 99 percent / AlCl3 / CH2Cl2 / 20 °C
3: 85 percent / Br2; AlCl3 / CH2Cl2
4: n-BuLi / tetrahydrofuran; hexane / 3 h / -78 - 20 °C
5: 2.38 g / aq. HCl / tetrahydrofuran / 2 h / 20 °C
6: 88 percent / Pd(OAc)2; P(o-Tol)3; Et3N / dimethylformamide / 2 h / 50 °C
7: H2O
References:
Faul;Ratz;Sullivan;Trankle;Winneroski [Journal of Organic Chemistry,2001,vol. 66,# 17,p. 5772 - 5782]
![Benzoic acid, 4-[1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]-, methyl ester](/CAS2/GIF/153559-48-9.gif)
153559-48-9
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153559-49-0
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6683-48-3
152 suppliers
$8.00/1g

153559-49-0
299 suppliers
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![Methyl 4-[(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)carbonyl]benzoate](/CAS/GIF/153559-45-6.gif)
153559-45-6
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$145.00/100mg

153559-49-0
299 suppliers
$25.00/5mg

6223-78-5
134 suppliers
$9.00/5g

153559-49-0
299 suppliers
$25.00/5mg