Bromoacetaldehyde dimethyl acetal synthesis
- Product Name:Bromoacetaldehyde dimethyl acetal
- CAS Number:7252-83-7
- Molecular formula:C4H9BrO2
- Molecular Weight:169.02
Yield:7252-83-7 98 %
Reaction Conditions:
with toluene-4-sulfonic acid in toluene at 78;Dean-Stark;
Steps:
2-bromoacetaldehyde dimethyl acetal 2
In a two- necked round bottom flask equipped with Dean stark,containing a solution of dry methanol (20 mL,0.49 mol) and p-toluenesulfonic acid (3.78 g, 10 mol%) in toluene (100 mL), The 2-bromoacetaldehyde 1 (10.0 g,0.22 mol) obtained in the previous step was slowly added, then the reaction mixture was stirred at 78 °C temperature for 24 h. After completing the reaction (almost 4 cc of water was separated in Dean-stark), a saturated aqueous solution of Na2S2O8(100 mL) was added to the vessel. Next, the aqueous phase was extracted with DCM (100 mL × 2). The organic phases were dried over Na2SO4. Finally, the resulting organic phase was concentrated under reduced pressure to obtain the corresponding product 2 (37.64 g, 0.22 mol,98%) as a colorless oil [51].
References:
Salavati, Reza;Sarrafi, Yaghoub;Tajbakhsh, Mahmood [Journal of Fluorescence,2022]
67-56-1
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