Chlormidazole synthesis
- Product Name:Chlormidazole
- CAS Number:3689-76-7
- Molecular formula:C15H13ClN2
- Molecular Weight:256.73
Yield: 95%
Reaction Conditions:
with iron;ammonium chloride at 68 - 70; for 48 h;Inert atmosphere;
Steps:
18.2
Step 2: Add 78.8mg (0.3mmol) of N-(4-chlorobenzyl)-2-nitroaniline to a 10mL reaction tube,Reduced iron powder 92.2mg (1.65mmol), ammonium chloride 88.3mg (1.65mmol), nitrogen protection,Add 6 mL of absolute ethanol with a syringe and heat and stir at 68-70°C for 48 hours.The reaction was cooled to room temperature and quenched with 5 mL of saturated aqueous sodium bicarbonate solution.Suction filtered through diatomaceous earth, the filtrate was extracted with dichloromethane (10 mL×3), and the organic phases were combined,After drying and concentration, 73.2 mg of the target compound was obtained, with a yield of 95%.
References:
China Agricultural University;An Jie;Li Hengchao;Zhang Yuntong;Lai Zemin;Yang Ruoyan;Yan Zihan;Ning Lei;Yao Shangchu CN111704579, 2020, A Location in patent:Paragraph 0132-0134; 0136-0138
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