Clorprenaline synthesis
- Product Name:Clorprenaline
- CAS Number:3811-25-4
- Molecular formula:C11H16ClNO
- Molecular Weight:213.7
27993-71-1
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75-31-0
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3811-25-4
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$196.00/10mg
Yield:3811-25-4 54%
Reaction Conditions:
Stage #1:1-(2-chlorophenyl)-2-hydroxyethanone;isopropylamine in 1,2-dichloro-ethane at 25; for 2 h;
Stage #2: with sodium tetrahydroborate in 1,2-dichloro-ethane at 0; for 2 h;
Steps:
3 Example 3: Synthesis of clorprenaline
Transfer the prepared 2-(2-chlorophenyl)-2-oxoacetaldehyde to a 50 mL pear-shaped bottle. 5 mL of 1,2-dichloroethane was added, and isopropylamine (141.8 mg) was added, and the reaction was carried out at 25 ° C for 2 h. Sodium borohydride (90.8 mg) was added in small portions to the system, and reacted at 0 ° C for 2 h. After removing the solvent by rotary distillation, it was separated by silica gel column (eluent, petroleum ether: ethyl acetate = 5:1 to 0:1), chlorpromazine was obtained, 232 mg of a white solid. The calculated yield was 54%.
References:
Beijing University of Chemical Technology;Du Hongguang;Zhang Shaojuan;Chen Ning CN110143886, 2019, A Location in patent:Paragraph 0094; 0096; 0097
2142-68-9
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$6.00/10g
3811-25-4
118 suppliers
$196.00/10mg