ETHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE synthesis
- Product Name:ETHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE
- CAS Number:3940-27-0
- Molecular formula:C5H12ClNO3
- Molecular Weight:169.61
64-17-5
56-45-1
3940-27-0
1. 5.4 mL of thionyl chloride (about two drops) was slowly added dropwise to a 100 mL three-necked flask containing 40 mL of ethanol under an ice-water bath and mechanical stirring, and stirring was continued for 1 hr after completion of the dropwise addition. 2. 6.00 g (57 mmol) of L-serine was added to the above reaction system and the reaction was heated to reflux for 10 hours. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give 9.05 g of the white solid product L-serine ethyl ester hydrochloride (III) in 93.4% yield.
Yield: 93.4%
Reaction Conditions:
with thionyl chloride for 11 h;Cooling with ice;Reflux;
Steps:
4 Embodiment 4, DL-serine ethyl ester hydrochloride (III) preparation of
In 100 ml of ethanol is added in three-mouth bottle 40 ml, under the condition of the mechanical stirring ice-water bath, slow adds by drops two chlorine Asia sulphone 5.4 ml, after dripping, continue to stir 1h, (II) 6.00g the L-serine (57mmol) inputs in three-mouth bottle, heating reflux reaction, the reaction time is 10h rear, reduced pressure distillation to remove the solvent, to obtain L-serine methyl ester hydrochloride (III) 9.05g, yield 93.4%
References:
Zhejiang University;Zhejiang Changming Pharmaceutical Co., Ltd.;Li, Jianjun;Zhou, Zhangxing;Chen, Jie;Sun, Jian;Ji, Youwei;Su, Weike CN105777611, 2016, A Location in patent:Paragraph 0052; 0053
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