ETHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE synthesis
- Product Name:ETHYL 2-AMINO-3-HYDROXYPROPANOATE HYDROCHLORIDE
- CAS Number:3940-27-0
- Molecular formula:C5H12ClNO3
- Molecular Weight:169.61
Yield: 93.4%
Reaction Conditions:
with thionyl chloride for 11 h;Cooling with ice;Reflux;
Steps:
4 Embodiment 4, DL-serine ethyl ester hydrochloride (III) preparation of
In 100 ml of ethanol is added in three-mouth bottle 40 ml, under the condition of the mechanical stirring ice-water bath, slow adds by drops two chlorine Asia sulphone 5.4 ml, after dripping, continue to stir 1h, (II) 6.00g the L-serine (57mmol) inputs in three-mouth bottle, heating reflux reaction, the reaction time is 10h rear, reduced pressure distillation to remove the solvent, to obtain L-serine methyl ester hydrochloride (III) 9.05g, yield 93.4%
References:
Zhejiang University;Zhejiang Changming Pharmaceutical Co., Ltd.;Li, Jianjun;Zhou, Zhangxing;Chen, Jie;Sun, Jian;Ji, Youwei;Su, Weike CN105777611, 2016, A Location in patent:Paragraph 0052; 0053
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![Serine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)](/CAS/GIF/3850-40-6.gif)