ChemicalBook CAS DataBase List Fenclorim

Fenclorim synthesis

8synthesis methods

Product Name:Fenclorim
CAS Number:3740-92-9
Molecular formula:C10H6Cl2N2
Molecular Weight:225.07

13566-71-7
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3740-92-9
221 suppliers
$8.00/10g

Yield:3740-92-9 95%

Reaction Conditions:

in trichlorophosphate

Steps:

1 Synthesis of Chloroacetamide Intermediate 6.
4,6-Dichloro-2-phenylpyrimidine (3): A slurry of diol 2 (39.08 g; 0.208 mol) in phosphorus oxychloride (124 mL; 1.33 mol) was heated from 75-120° C. over 45 min. After 20 h at 120° C. the volatiles were removed in vacuo. The resulting tan solid was added to crushed ice (600 mL) and this suspension was stirred for 2 h at rt, collected by filtration, washed with water and dried to a constant weight under high vacuum giving a tan solid (44.34 g; 95%). ¹H NMR (200 MHZ, CDCl₃) δ 8.44 (m, 2H), 7.51 (m, 3H), 7.27 (s, 1H).

References:

Castelhano, Arlindo;McKibben, Bryan;Steinig, Arno;Collington, Eric US2003/162764, 2003, A1

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13566-71-7
48 suppliers
$9.00/250mg

3740-92-9
221 suppliers
$8.00/10g

References

1193-21-1 Synthesis