ChemicalBook CAS DataBase List Glycidyl Palmitate

Glycidyl Palmitate synthesis

6synthesis methods

Product Name:Glycidyl Palmitate
CAS Number:7501-44-2
Molecular formula:C19H36O3
Molecular Weight:312.49

57-10-3 Synthesis

57-10-3
529 suppliers
$5.00/250mg

106-89-8 Synthesis

106-89-8
725 suppliers
$9.00/10 g

7501-44-2
24 suppliers
$250.00/10x1ml

Yield:7501-44-2 63.65%

Reaction Conditions:

with tetrabutylammomium bromide;sodium hydroxide in Petroleum ether at 50; for 5 h;Inert atmosphere;

Steps:

1.A A.
As shown in reaction 1a below, glycidyl chloride (832.68 mg, 9.0 mmol, 1.8eq.), R1-OH (1 eq., R1=palmitoyl), NaOH (1.8 eq.) and n-Bu₄NBr (0.05 eq.) as a catalyst were added to 1.5 ml of PE (petroleum ether) in a nitrogen atmosphere (N2-purge). And, the temperature was raised to 50° C. and it was stirred for 5 hours. The reaction solution was diluted with 30 ml of PE and then filtered. The organic layer was dehydrated with Na₂SO₄, and filtered, and then concentrated. The concentrate was purified with a flash column (PE:EA (ethyl acetate)=50:1) to obtain the target compound A (R1=palmitoyl, yield=63.65%).

References:

ENZYCHEM LIFESCIENCES CORPORATION;SOHN, Ki Young;KIM, Jae Wha;YOON, Sun Young;YOO, Chang Hyun;JEONG, Jin Seon US2021/2197, 2021, A1 Location in patent:Paragraph 0040

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