ChemicalBook CAS DataBase List Methyl 4-amino-3-methylbenzoate

Methyl 4-amino-3-methylbenzoate synthesis

4synthesis methods

Product Name:Methyl 4-amino-3-methylbenzoate
CAS Number:18595-14-7
Molecular formula:C9H11NO2
Molecular Weight:165.19

3113-71-1 Synthesis

3113-71-1
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$6.00/25g

18595-14-7
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$8.00/5g

Yield:18595-14-7 99%

Reaction Conditions:

with H₂;palladium-carbon in methanol;

Steps:

17.a Example 17

(a) Methyl 4-amino-3-methylbenzoate. To a solution of 3-methyl-4-nitrobenzoic acid (6.50 g, 33.3 mmol) in 100 mL of MeOH was added 700 mg of 5% Pd/C. The mixture was hydrogenated at 48 psi H₂ for 24 hours, the catalyst was removed by suction filtration, and the filtrate was concentrated under reduced pressure. The title compound was obtained as a white solid (99%). ¹H NMR (CDCl₃) δ: 2.19 (s, 3H), 3.85 (s, 3H), 4.20 (br s, 2H), 6.65 (d, 2H, J = 8.1Hz), 7.72 (d, 2H, J = 8.1Hz), 7.76 (s, 1H). Anal. (C₉H₁₁NO₂) C, H, N.

References:

EP1109560,2003,B1

24078-21-5 Synthesis