Methyl 4-amino-3-methylbenzoate synthesis
- Product Name:Methyl 4-amino-3-methylbenzoate
- CAS Number:18595-14-7
- Molecular formula:C9H11NO2
- Molecular Weight:165.19
3113-71-1
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18595-14-7
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$8.00/5g
Yield:18595-14-7 99%
Reaction Conditions:
with H2;palladium-carbon in methanol;
Steps:
17.a Example 17
(a) Methyl 4-amino-3-methylbenzoate. To a solution of 3-methyl-4-nitrobenzoic acid (6.50 g, 33.3 mmol) in 100 mL of MeOH was added 700 mg of 5% Pd/C. The mixture was hydrogenated at 48 psi H2 for 24 hours, the catalyst was removed by suction filtration, and the filtrate was concentrated under reduced pressure. The title compound was obtained as a white solid (99%). 1H NMR (CDCl3) δ: 2.19 (s, 3H), 3.85 (s, 3H), 4.20 (br s, 2H), 6.65 (d, 2H, J = 8.1Hz), 7.72 (d, 2H, J = 8.1Hz), 7.76 (s, 1H). Anal. (C9H11NO2) C, H, N.
References:
EP1109560,2003,B1
24078-21-5
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18595-14-7
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$8.00/5g
619-50-1
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$17.00/25g
676-58-4
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$15.00/25ml
18358-63-9
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$15.00/1g
18595-14-7
305 suppliers
$8.00/5g